Autophagy in prostate cancer and androgen suppression therapy

Elio Ziparo, Simonetta Petrungaro, Elettra Sara Marini, Donatella Starace, Silvia Conti, Antonio Facchiano, Antonio Filippini, Claudia Giampietri

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including melanoma, breast and prostate cancer. In the present review, recent advances in an understanding of the involvement of autophagy in prostate cancer treatment are described. The regulatory effects of androgens on prostate cancer cell autophagy are particularly discussed in order to highlight the effects of autophagy modulation during androgen deprivation. A critical evaluation of the studies examined in the present review suggests the attractive possibility of autophagy inhibition combined with hormonal therapy as a promising approach for prostate cancer treatment.

Original languageEnglish
Pages (from-to)12090-12106
Number of pages17
JournalInternational Journal of Molecular Sciences
Volume14
Issue number6
DOIs
Publication statusPublished - 2013

Fingerprint

Oncology
Autophagy
Androgens
therapy
Prostatic Neoplasms
cancer
retarding
Tumors
Cells
Modulation
deprivation
Therapeutics
progressions
breast
Melanoma
Neoplasms
tumors
Breast Neoplasms
modulation
evaluation

Keywords

  • Androgen deprivation therapy
  • Apoptosis
  • Autophagy
  • Prostate cancer

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Spectroscopy
  • Inorganic Chemistry
  • Catalysis
  • Molecular Biology
  • Computer Science Applications
  • Medicine(all)

Cite this

Ziparo, E., Petrungaro, S., Marini, E. S., Starace, D., Conti, S., Facchiano, A., ... Giampietri, C. (2013). Autophagy in prostate cancer and androgen suppression therapy. International Journal of Molecular Sciences, 14(6), 12090-12106. https://doi.org/10.3390/ijms140612090

Autophagy in prostate cancer and androgen suppression therapy. / Ziparo, Elio; Petrungaro, Simonetta; Marini, Elettra Sara; Starace, Donatella; Conti, Silvia; Facchiano, Antonio; Filippini, Antonio; Giampietri, Claudia.

In: International Journal of Molecular Sciences, Vol. 14, No. 6, 2013, p. 12090-12106.

Research output: Contribution to journalArticle

Ziparo, E, Petrungaro, S, Marini, ES, Starace, D, Conti, S, Facchiano, A, Filippini, A & Giampietri, C 2013, 'Autophagy in prostate cancer and androgen suppression therapy', International Journal of Molecular Sciences, vol. 14, no. 6, pp. 12090-12106. https://doi.org/10.3390/ijms140612090
Ziparo, Elio ; Petrungaro, Simonetta ; Marini, Elettra Sara ; Starace, Donatella ; Conti, Silvia ; Facchiano, Antonio ; Filippini, Antonio ; Giampietri, Claudia. / Autophagy in prostate cancer and androgen suppression therapy. In: International Journal of Molecular Sciences. 2013 ; Vol. 14, No. 6. pp. 12090-12106.
@article{ca7a10c007134dfd9b6677e28b2e4762,
title = "Autophagy in prostate cancer and androgen suppression therapy",
abstract = "The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including melanoma, breast and prostate cancer. In the present review, recent advances in an understanding of the involvement of autophagy in prostate cancer treatment are described. The regulatory effects of androgens on prostate cancer cell autophagy are particularly discussed in order to highlight the effects of autophagy modulation during androgen deprivation. A critical evaluation of the studies examined in the present review suggests the attractive possibility of autophagy inhibition combined with hormonal therapy as a promising approach for prostate cancer treatment.",
keywords = "Androgen deprivation therapy, Apoptosis, Autophagy, Prostate cancer",
author = "Elio Ziparo and Simonetta Petrungaro and Marini, {Elettra Sara} and Donatella Starace and Silvia Conti and Antonio Facchiano and Antonio Filippini and Claudia Giampietri",
year = "2013",
doi = "10.3390/ijms140612090",
language = "English",
volume = "14",
pages = "12090--12106",
journal = "International Journal of Molecular Sciences",
issn = "1661-6596",
publisher = "MDPI AG",
number = "6",

}

TY - JOUR

T1 - Autophagy in prostate cancer and androgen suppression therapy

AU - Ziparo, Elio

AU - Petrungaro, Simonetta

AU - Marini, Elettra Sara

AU - Starace, Donatella

AU - Conti, Silvia

AU - Facchiano, Antonio

AU - Filippini, Antonio

AU - Giampietri, Claudia

PY - 2013

Y1 - 2013

N2 - The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including melanoma, breast and prostate cancer. In the present review, recent advances in an understanding of the involvement of autophagy in prostate cancer treatment are described. The regulatory effects of androgens on prostate cancer cell autophagy are particularly discussed in order to highlight the effects of autophagy modulation during androgen deprivation. A critical evaluation of the studies examined in the present review suggests the attractive possibility of autophagy inhibition combined with hormonal therapy as a promising approach for prostate cancer treatment.

AB - The role of autophagy is known to be highly complex and context-dependent, leading to both cancer suppression and progression in several tumors including melanoma, breast and prostate cancer. In the present review, recent advances in an understanding of the involvement of autophagy in prostate cancer treatment are described. The regulatory effects of androgens on prostate cancer cell autophagy are particularly discussed in order to highlight the effects of autophagy modulation during androgen deprivation. A critical evaluation of the studies examined in the present review suggests the attractive possibility of autophagy inhibition combined with hormonal therapy as a promising approach for prostate cancer treatment.

KW - Androgen deprivation therapy

KW - Apoptosis

KW - Autophagy

KW - Prostate cancer

UR - http://www.scopus.com/inward/record.url?scp=84879019799&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879019799&partnerID=8YFLogxK

U2 - 10.3390/ijms140612090

DO - 10.3390/ijms140612090

M3 - Article

VL - 14

SP - 12090

EP - 12106

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1661-6596

IS - 6

ER -