Autophagy in stem and progenitor cells

Carlo Rodolfo, Sabrina Di Bartolomeo, Francesco Cecconi

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Autophagy is a highly conserved cellular process, responsible for the degradation and recycling of damaged and/or outlived proteins and organelles. This is the major cellular pathway, acting throughout the formation of cytosolic vesicles, called autophagosomes, for the delivering to lysosome. Recycling of cellular components through autophagy is a crucial step for cell homeostasis as well as for tissue remodelling during development. Impairment of this process has been related to the pathogenesis of various diseases, such as cancer and neurodegeneration, to the response to bacterial and viral infections, and to ageing. The ability of stem cells to self-renew and differentiate into the mature cells of the body renders this unique type of cell highly crucial to development and tissue renewal, not least in various diseases. During the last two decades, extensive knowledge about autophagy roles and regulation in somatic cells has been acquired; however, the picture about the role and the regulation of autophagy in the different types of stem cells is still largely unknown. Autophagy is a major player in the quality control and maintenance of cellular homeostasis, both crucial factors for stem cells during an organism's life. In this review, we have highlighted the most significant advances in the comprehension of autophagy regulation in embryonic and tissue stem cells, as well as in cancer stem cells and induced pluripotent cells.

Original languageEnglish
Pages (from-to)475-496
Number of pages22
JournalCellular and Molecular Life Sciences
Volume73
Issue number3
DOIs
Publication statusE-pub ahead of print - Oct 26 2015

Fingerprint

Autophagy
Stem Cells
Recycling
Homeostasis
Stem Cell Factor
Aptitude
Neoplastic Stem Cells
Virus Diseases
Embryonic Stem Cells
Lysosomes
Bacterial Infections
Quality Control
Organelles
Maintenance
Neoplasms
Proteins

Keywords

  • Autophagy
  • Progenitor cells
  • Stem cells

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Molecular Medicine
  • Pharmacology
  • Cellular and Molecular Neuroscience

Cite this

Autophagy in stem and progenitor cells. / Rodolfo, Carlo; Di Bartolomeo, Sabrina; Cecconi, Francesco.

In: Cellular and Molecular Life Sciences, Vol. 73, No. 3, 26.10.2015, p. 475-496.

Research output: Contribution to journalArticle

Rodolfo, Carlo ; Di Bartolomeo, Sabrina ; Cecconi, Francesco. / Autophagy in stem and progenitor cells. In: Cellular and Molecular Life Sciences. 2015 ; Vol. 73, No. 3. pp. 475-496.
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