Autophagy in zika virus infection: A possible therapeutic target to counteract viral replication

Rossella Gratton, Almerinda Agrelli, Paola Maura Tricarico, Lucas Brandão, Sergio Crovella

Research output: Contribution to journalArticle

Abstract

Zika virus (ZIKV) still constitutes a public health concern, however, no vaccines or therapies are currently approved for treatment. A fundamental process involved in ZIKV infection is autophagy, a cellular catabolic pathway delivering cytoplasmic cargo to the lysosome for degradation—considered as a primordial form of innate immunity against invading microorganisms. ZIKV is thought to inhibit the Akt-mTOR signaling pathway, which causes aberrant activation of autophagy promoting viral replication and propagation. It is therefore appealing to study the role of autophagic molecular effectors during viral infection to identify potential targets for anti-ZIKV therapeutic intervention.

Original languageEnglish
Article number1048
JournalInternational Journal of Molecular Sciences
Volume20
Issue number5
DOIs
Publication statusPublished - Mar 1 2019

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Keywords

  • Akt-mTOR
  • Autophagy
  • Innate immunity
  • Therapeutic targets
  • Zika virus

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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