TY - JOUR
T1 - Autophagy manipulation as a strategy for efficient anticancer therapies
T2 - Possible consequences
AU - Cirone, Mara
AU - Gilardini Montani, Maria Saveria
AU - Granato, Marisa
AU - Garufi, Alessia
AU - Faggioni, Alberto
AU - D'Orazi, Gabriella
PY - 2019/6/14
Y1 - 2019/6/14
N2 - Autophagy is a catabolic process whose activation may help cancer cells to adapt to cellular stress although, in some instances, it can induce cell death. Autophagy stimulation or inhibition has been considered an opportunity to treat cancer, especially in combination with anticancer therapies, although autophagy manipulation may be viewed as controversial. Thus, whether to induce or to inhibit autophagy may be the best option in the different cancer patients is still matter of debate. Her we will recapitulate the possible advantages or disadvantages of manipulating autophagy in cancer, not only with the aim to obtain cancer cell death and disable oncogenes, but also to evaluate its interplay with the immune response which is fundamental for the success of anticancer therapies.
AB - Autophagy is a catabolic process whose activation may help cancer cells to adapt to cellular stress although, in some instances, it can induce cell death. Autophagy stimulation or inhibition has been considered an opportunity to treat cancer, especially in combination with anticancer therapies, although autophagy manipulation may be viewed as controversial. Thus, whether to induce or to inhibit autophagy may be the best option in the different cancer patients is still matter of debate. Her we will recapitulate the possible advantages or disadvantages of manipulating autophagy in cancer, not only with the aim to obtain cancer cell death and disable oncogenes, but also to evaluate its interplay with the immune response which is fundamental for the success of anticancer therapies.
KW - Autophagy
KW - Cancer
KW - Chloroquine (CQ)
KW - Endoplasmic reticulum (ER stress)
KW - HSF1
KW - Hydroxichloroquine (HCQ)
KW - Immunogenic cell death (ICD)
KW - NRF2
KW - p53
KW - Unfolded protein response (UPR)
UR - http://www.scopus.com/inward/record.url?scp=85067303452&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85067303452&partnerID=8YFLogxK
U2 - 10.1186/s13046-019-1275-z
DO - 10.1186/s13046-019-1275-z
M3 - Review article
C2 - 31200739
AN - SCOPUS:85067303452
VL - 38
SP - 262
JO - Journal of Experimental and Clinical Cancer Research
JF - Journal of Experimental and Clinical Cancer Research
SN - 0392-9078
IS - 1
ER -