Autophagy manipulation as a strategy for efficient anticancer therapies: Possible consequences

Mara Cirone, Maria Saveria Gilardini Montani, Marisa Granato, Alessia Garufi, Alberto Faggioni, Gabriella D'Orazi

Research output: Contribution to journalReview article

Abstract

Autophagy is a catabolic process whose activation may help cancer cells to adapt to cellular stress although, in some instances, it can induce cell death. Autophagy stimulation or inhibition has been considered an opportunity to treat cancer, especially in combination with anticancer therapies, although autophagy manipulation may be viewed as controversial. Thus, whether to induce or to inhibit autophagy may be the best option in the different cancer patients is still matter of debate. Her we will recapitulate the possible advantages or disadvantages of manipulating autophagy in cancer, not only with the aim to obtain cancer cell death and disable oncogenes, but also to evaluate its interplay with the immune response which is fundamental for the success of anticancer therapies.

Original languageEnglish
Pages (from-to)262
JournalJournal of Experimental and Clinical Cancer Research
Volume38
Issue number1
DOIs
Publication statusPublished - Jun 14 2019

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Keywords

  • Autophagy
  • Cancer
  • Chloroquine (CQ)
  • Endoplasmic reticulum (ER stress)
  • HSF1
  • Hydroxichloroquine (HCQ)
  • Immunogenic cell death (ICD)
  • NRF2
  • p53
  • Unfolded protein response (UPR)

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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