Autophagy plays an important role in the containment of HIV-1 in nonprogressor-infected patients

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Abstract

Recent in vitro studies have suggested that autophagy may play a role in both HIV-1 replication and disease progression. In this study we investigated whether autophagy protects the small proportion of HIV-1 infected individuals who remain clinically stable for years in the absence of antiretroviral therapy, these named long-term nonprogressors (LTNP) and elite controllers (EC). We found that peripheral blood mononuclear cells (PBMC) of the HIV-1 controllers present a significantly higher amount of autophagic vesicles associated with an increased expression of autophagic markers with respect to normal progressors. Of note, ex vivo treatment of PBMC from the HIV-1 controllers with the MTOR inhibitor rapamycin results in a more efficient autophagic response, leading to a reduced viral production. These data lead us to propose that autophagy contributes to limiting viral pathogenesis in HIV-1 controllers by targeting viral components for degradation.

Original languageEnglish
Pages (from-to)1167-1178
Number of pages12
JournalAutophagy
Volume10
Issue number7
DOIs
Publication statusPublished - 2014

Keywords

  • AMBRA1
  • ATG5
  • Autophagy
  • BECN1
  • Cell death
  • Elite controllers
  • HIV-1
  • Long-term nonprogressors

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Medicine(all)

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