Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion

Fabio Blandini; Richard H P Porter; J. Timothy Greenamyre

doi:10.1016/0304-3940(95)11292-5

Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion

Fabio Blandini, Richard H P Porter, J. Timothy Greenamyre

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article

Abstract

A unilateral lesion of the subthalamic nucleus (STN) induced, in the short-term (≤ week), an ipsilateral decrease in [³H]dihydrorotenone binding to complex I in entopeduncular nucleus and substantia nigra pars reticulata (SNr). A slight reduction of [³H]MK-801 binding to N-methyl-d-aspartate (NMDA) receptors in the ipsilateral SNr was also found, whereas no changes in [³H]α-amino-3-hydroxy-5-methylisoxazole propionic acid binding were observed. The complex I decrease likely reflects a reduction in neuronal activity subsequent to the interruption of excitatory signaling from STN. The unexpected decrease in [³H]MK-801 binding in SNr may be related to presynaptic NMDA receptor modifications.

Original language	English
Pages (from-to)	99-102
Number of pages	4
Journal	Neuroscience Letters
Volume	186
Issue number	2-3
DOIs	https://doi.org/10.1016/0304-3940(95)11292-5
Publication status	Published - Feb 17 1995

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Keywords

Amino-3-hydroxy-5-methylisoxazole propionic acid receptors
Autoradiography
Complex I
N-Methyl-d-aspartate receptors
Rotenone
Subthalamic nucleus

ASJC Scopus subject areas

Neuroscience(all)

Cite this

Blandini, F., Porter, R. H. P., & Greenamyre, J. T. (1995). Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion. Neuroscience Letters, 186(2-3), 99-102. https://doi.org/10.1016/0304-3940(95)11292-5

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abstract = "A unilateral lesion of the subthalamic nucleus (STN) induced, in the short-term (≤ week), an ipsilateral decrease in [3H]dihydrorotenone binding to complex I in entopeduncular nucleus and substantia nigra pars reticulata (SNr). A slight reduction of [3H]MK-801 binding to N-methyl-d-aspartate (NMDA) receptors in the ipsilateral SNr was also found, whereas no changes in [3H]α-amino-3-hydroxy-5-methylisoxazole propionic acid binding were observed. The complex I decrease likely reflects a reduction in neuronal activity subsequent to the interruption of excitatory signaling from STN. The unexpected decrease in [3H]MK-801 binding in SNr may be related to presynaptic NMDA receptor modifications.",

keywords = "Amino-3-hydroxy-5-methylisoxazole propionic acid receptors, Autoradiography, Complex I, N-Methyl-d-aspartate receptors, Rotenone, Subthalamic nucleus",

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N2 - A unilateral lesion of the subthalamic nucleus (STN) induced, in the short-term (≤ week), an ipsilateral decrease in [3H]dihydrorotenone binding to complex I in entopeduncular nucleus and substantia nigra pars reticulata (SNr). A slight reduction of [3H]MK-801 binding to N-methyl-d-aspartate (NMDA) receptors in the ipsilateral SNr was also found, whereas no changes in [3H]α-amino-3-hydroxy-5-methylisoxazole propionic acid binding were observed. The complex I decrease likely reflects a reduction in neuronal activity subsequent to the interruption of excitatory signaling from STN. The unexpected decrease in [3H]MK-801 binding in SNr may be related to presynaptic NMDA receptor modifications.

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10.1016/0304-3940(95)11292-5