A unilateral lesion of the subthalamic nucleus (STN) induced, in the short-term (≤ week), an ipsilateral decrease in [3H]dihydrorotenone binding to complex I in entopeduncular nucleus and substantia nigra pars reticulata (SNr). A slight reduction of [3H]MK-801 binding to N-methyl-d-aspartate (NMDA) receptors in the ipsilateral SNr was also found, whereas no changes in [3H]α-amino-3-hydroxy-5-methylisoxazole propionic acid binding were observed. The complex I decrease likely reflects a reduction in neuronal activity subsequent to the interruption of excitatory signaling from STN. The unexpected decrease in [3H]MK-801 binding in SNr may be related to presynaptic NMDA receptor modifications.
- Amino-3-hydroxy-5-methylisoxazole propionic acid receptors
- Complex I
- N-Methyl-d-aspartate receptors
- Subthalamic nucleus
ASJC Scopus subject areas