Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion

Fabio Blandini; Richard H P Porter; J. Timothy Greenamyre

doi:10.1016/0304-3940(95)11292-5

Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion

Fabio Blandini, Richard H P Porter, J. Timothy Greenamyre

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

A unilateral lesion of the subthalamic nucleus (STN) induced, in the short-term (≤ week), an ipsilateral decrease in [³H]dihydrorotenone binding to complex I in entopeduncular nucleus and substantia nigra pars reticulata (SNr). A slight reduction of [³H]MK-801 binding to N-methyl-d-aspartate (NMDA) receptors in the ipsilateral SNr was also found, whereas no changes in [³H]α-amino-3-hydroxy-5-methylisoxazole propionic acid binding were observed. The complex I decrease likely reflects a reduction in neuronal activity subsequent to the interruption of excitatory signaling from STN. The unexpected decrease in [³H]MK-801 binding in SNr may be related to presynaptic NMDA receptor modifications.

Original language	English
Pages (from-to)	99-102
Number of pages	4
Journal	Neuroscience Letters
Volume	186
Issue number	2-3
DOIs	https://doi.org/10.1016/0304-3940(95)11292-5
Publication status	Published - Feb 17 1995

Keywords

Amino-3-hydroxy-5-methylisoxazole propionic acid receptors
Autoradiography
Complex I
N-Methyl-d-aspartate receptors
Rotenone
Subthalamic nucleus

ASJC Scopus subject areas

Neuroscience(all)

Access to Document

10.1016/0304-3940(95)11292-5

Fingerprint Dive into the research topics of 'Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion'. Together they form a unique fingerprint.

Cite this

@article{096f5442a5004d8bb858314d842c202c,

title = "Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion",

abstract = "A unilateral lesion of the subthalamic nucleus (STN) induced, in the short-term (≤ week), an ipsilateral decrease in [3H]dihydrorotenone binding to complex I in entopeduncular nucleus and substantia nigra pars reticulata (SNr). A slight reduction of [3H]MK-801 binding to N-methyl-d-aspartate (NMDA) receptors in the ipsilateral SNr was also found, whereas no changes in [3H]α-amino-3-hydroxy-5-methylisoxazole propionic acid binding were observed. The complex I decrease likely reflects a reduction in neuronal activity subsequent to the interruption of excitatory signaling from STN. The unexpected decrease in [3H]MK-801 binding in SNr may be related to presynaptic NMDA receptor modifications.",

keywords = "Amino-3-hydroxy-5-methylisoxazole propionic acid receptors, Autoradiography, Complex I, N-Methyl-d-aspartate receptors, Rotenone, Subthalamic nucleus",

author = "Fabio Blandini and Porter, {Richard H P} and Greenamyre, {J. Timothy}",

year = "1995",

month = feb,

day = "17",

doi = "10.1016/0304-3940(95)11292-5",

language = "English",

volume = "186",

pages = "99--102",

journal = "Neuroscience Letters",

issn = "0304-3940",

publisher = "Elsevier Ireland Ltd",

number = "2-3",

}

TY - JOUR

T1 - Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion

AU - Blandini, Fabio

AU - Porter, Richard H P

AU - Greenamyre, J. Timothy

PY - 1995/2/17

Y1 - 1995/2/17

N2 - A unilateral lesion of the subthalamic nucleus (STN) induced, in the short-term (≤ week), an ipsilateral decrease in [3H]dihydrorotenone binding to complex I in entopeduncular nucleus and substantia nigra pars reticulata (SNr). A slight reduction of [3H]MK-801 binding to N-methyl-d-aspartate (NMDA) receptors in the ipsilateral SNr was also found, whereas no changes in [3H]α-amino-3-hydroxy-5-methylisoxazole propionic acid binding were observed. The complex I decrease likely reflects a reduction in neuronal activity subsequent to the interruption of excitatory signaling from STN. The unexpected decrease in [3H]MK-801 binding in SNr may be related to presynaptic NMDA receptor modifications.

AB - A unilateral lesion of the subthalamic nucleus (STN) induced, in the short-term (≤ week), an ipsilateral decrease in [3H]dihydrorotenone binding to complex I in entopeduncular nucleus and substantia nigra pars reticulata (SNr). A slight reduction of [3H]MK-801 binding to N-methyl-d-aspartate (NMDA) receptors in the ipsilateral SNr was also found, whereas no changes in [3H]α-amino-3-hydroxy-5-methylisoxazole propionic acid binding were observed. The complex I decrease likely reflects a reduction in neuronal activity subsequent to the interruption of excitatory signaling from STN. The unexpected decrease in [3H]MK-801 binding in SNr may be related to presynaptic NMDA receptor modifications.

KW - Amino-3-hydroxy-5-methylisoxazole propionic acid receptors

KW - Autoradiography

KW - Complex I

KW - N-Methyl-d-aspartate receptors

KW - Rotenone

KW - Subthalamic nucleus

UR - http://www.scopus.com/inward/record.url?scp=0028912583&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028912583&partnerID=8YFLogxK

U2 - 10.1016/0304-3940(95)11292-5

DO - 10.1016/0304-3940(95)11292-5

M3 - Article

C2 - 7777208

AN - SCOPUS:0028912583

VL - 186

SP - 99

EP - 102

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

IS - 2-3

ER -

Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this