Abstract
A unilateral lesion of the subthalamic nucleus (STN) induced, in the short-term (≤ week), an ipsilateral decrease in [3H]dihydrorotenone binding to complex I in entopeduncular nucleus and substantia nigra pars reticulata (SNr). A slight reduction of [3H]MK-801 binding to N-methyl-d-aspartate (NMDA) receptors in the ipsilateral SNr was also found, whereas no changes in [3H]α-amino-3-hydroxy-5-methylisoxazole propionic acid binding were observed. The complex I decrease likely reflects a reduction in neuronal activity subsequent to the interruption of excitatory signaling from STN. The unexpected decrease in [3H]MK-801 binding in SNr may be related to presynaptic NMDA receptor modifications.
| Original language | English |
|---|---|
| Pages (from-to) | 99-102 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 186 |
| Issue number | 2-3 |
| DOIs | |
| Publication status | Published - Feb 17 1995 |
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Keywords
- Amino-3-hydroxy-5-methylisoxazole propionic acid receptors
- Autoradiography
- Complex I
- N-Methyl-d-aspartate receptors
- Rotenone
- Subthalamic nucleus
ASJC Scopus subject areas
- Neuroscience(all)
Cite this
Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion. / Blandini, Fabio; Porter, Richard H P; Greenamyre, J. Timothy.
In: Neuroscience Letters, Vol. 186, No. 2-3, 17.02.1995, p. 99-102.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion
AU - Blandini, Fabio
AU - Porter, Richard H P
AU - Greenamyre, J. Timothy
PY - 1995/2/17
Y1 - 1995/2/17
N2 - A unilateral lesion of the subthalamic nucleus (STN) induced, in the short-term (≤ week), an ipsilateral decrease in [3H]dihydrorotenone binding to complex I in entopeduncular nucleus and substantia nigra pars reticulata (SNr). A slight reduction of [3H]MK-801 binding to N-methyl-d-aspartate (NMDA) receptors in the ipsilateral SNr was also found, whereas no changes in [3H]α-amino-3-hydroxy-5-methylisoxazole propionic acid binding were observed. The complex I decrease likely reflects a reduction in neuronal activity subsequent to the interruption of excitatory signaling from STN. The unexpected decrease in [3H]MK-801 binding in SNr may be related to presynaptic NMDA receptor modifications.
AB - A unilateral lesion of the subthalamic nucleus (STN) induced, in the short-term (≤ week), an ipsilateral decrease in [3H]dihydrorotenone binding to complex I in entopeduncular nucleus and substantia nigra pars reticulata (SNr). A slight reduction of [3H]MK-801 binding to N-methyl-d-aspartate (NMDA) receptors in the ipsilateral SNr was also found, whereas no changes in [3H]α-amino-3-hydroxy-5-methylisoxazole propionic acid binding were observed. The complex I decrease likely reflects a reduction in neuronal activity subsequent to the interruption of excitatory signaling from STN. The unexpected decrease in [3H]MK-801 binding in SNr may be related to presynaptic NMDA receptor modifications.
KW - Amino-3-hydroxy-5-methylisoxazole propionic acid receptors
KW - Autoradiography
KW - Complex I
KW - N-Methyl-d-aspartate receptors
KW - Rotenone
KW - Subthalamic nucleus
UR - http://www.scopus.com/inward/record.url?scp=0028912583&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028912583&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(95)11292-5
DO - 10.1016/0304-3940(95)11292-5
M3 - Article
VL - 186
SP - 99
EP - 102
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2-3
ER -