Autoradiographic study of mitochondrial complex I and glutamate receptors in the basal ganglia of rats after unilateral subthalamic lesion

Fabio Blandini, Richard H P Porter, J. Timothy Greenamyre

Research output: Contribution to journalArticle

Abstract

A unilateral lesion of the subthalamic nucleus (STN) induced, in the short-term (≤ week), an ipsilateral decrease in [3H]dihydrorotenone binding to complex I in entopeduncular nucleus and substantia nigra pars reticulata (SNr). A slight reduction of [3H]MK-801 binding to N-methyl-d-aspartate (NMDA) receptors in the ipsilateral SNr was also found, whereas no changes in [3H]α-amino-3-hydroxy-5-methylisoxazole propionic acid binding were observed. The complex I decrease likely reflects a reduction in neuronal activity subsequent to the interruption of excitatory signaling from STN. The unexpected decrease in [3H]MK-801 binding in SNr may be related to presynaptic NMDA receptor modifications.

Original languageEnglish
Pages (from-to)99-102
Number of pages4
JournalNeuroscience Letters
Volume186
Issue number2-3
DOIs
Publication statusPublished - Feb 17 1995

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Keywords

  • Amino-3-hydroxy-5-methylisoxazole propionic acid receptors
  • Autoradiography
  • Complex I
  • N-Methyl-d-aspartate receptors
  • Rotenone
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

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