Autoradiographical analysis of excitatory amino acid binding sites in rat hippocampus during the development of hippocampal kindling

A. Vezzani, R. Serafini, R. Samanin, A. C. Foster

Research output: Contribution to journalArticlepeer-review

Abstract

Binding sites for excitatory amino acids have been determined by autoradiographical procedures in the rat hippocampus and striatum during hippocampal kindling. The binding sites measured were the N-methyl-d-aspartate (NMDA)-sensitive sites for l-[3H]glutamate and [3H]MK-801 sites (transmitter recognition site and ion channel of the NMDA receptor, respectively), [3H]α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) sites (quisqualate receptor), [3H]kainate sites (kainate receptor) and NMDA-insensitive sites for l-[3H]glutamate. In general, little change was apparent in the hippocampus or striatum for any of these binding sites when assessed 48 h after attaining stages 1 2, 3 or 5 of kindling. These results suggest that hippocampal kindling does not bring about a change in the excitatory amino acid receptor binding sites examined, and that the appearance of an NMDA receptor-mediated component to synaptic responses in the hippocampus produced by kindling15, cannot be explained on this basis.

Original languageEnglish
Pages (from-to)113-121
Number of pages9
JournalBrain Research
Volume526
Issue number1
DOIs
Publication statusPublished - Aug 27 1990

Keywords

  • Epilepsy
  • Kainate receptor
  • MK-801
  • N-Methyl-d-aspartate receptor
  • Quisqualate receptor

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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