TY - JOUR
T1 - Autosomal dominant psychiatric disorders and mitochondrial DNA multiple deletions
T2 - Report of a family
AU - Mancuso, Michelangelo
AU - Ricci, Giulia
AU - Choub, Anna
AU - Filosto, Massimiliano
AU - DiMauro, Salvatore
AU - Davidzon, Guido
AU - Tessa, Alessandra
AU - Santorelli, Filippo M.
AU - Murri, Luigi
AU - Siciliano, Gabriele
PY - 2008/2
Y1 - 2008/2
N2 - Background: Psychiatric problems, including bipolar affective disorder (BD) and schizophrenia, are common in mitochondrial diseases (MD) and frequently precede the diagnosis of mitochondrial dysfunction. However, they are rarely the only persistent manifestation of a MD and they are usually associated with other neurological or non-neurological features. Case report: Here, we describe an Italian family with multiple deletions of mtDNA in muscle, in which BD, schizophrenia, and depression recurred over several generations in the absence of other major signs of mitochondrial dysfunction. Conclusion: In patients with positive family history of psychiatric problems, the possibility of MD should be kept in mind, even in absence of other canonical features of mitochondrial encephalomyopathies.
AB - Background: Psychiatric problems, including bipolar affective disorder (BD) and schizophrenia, are common in mitochondrial diseases (MD) and frequently precede the diagnosis of mitochondrial dysfunction. However, they are rarely the only persistent manifestation of a MD and they are usually associated with other neurological or non-neurological features. Case report: Here, we describe an Italian family with multiple deletions of mtDNA in muscle, in which BD, schizophrenia, and depression recurred over several generations in the absence of other major signs of mitochondrial dysfunction. Conclusion: In patients with positive family history of psychiatric problems, the possibility of MD should be kept in mind, even in absence of other canonical features of mitochondrial encephalomyopathies.
KW - Bipolar disorder
KW - Mitochondrial disease
KW - mtDNA
KW - Psychiatric symptoms
KW - Schizophrenia
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U2 - 10.1016/j.jad.2007.05.016
DO - 10.1016/j.jad.2007.05.016
M3 - Article
C2 - 17588675
AN - SCOPUS:37349031029
VL - 106
SP - 173
EP - 177
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 1-2
ER -