TY - JOUR
T1 - Autotomy and central nervous system neuropeptides after section of the sciatic nerve in rats of different strains
AU - Panerai, Alberto E.
AU - Sacerdote, Paola
AU - Brini, Anna
AU - Bianchi, Mauro
AU - Mantegazza, Paolo
PY - 1987
Y1 - 1987
N2 - Autotomy and the concentrations of beta-endorphin and Met-enkephalin in brain areas and the spinal cord were measured in Sprague Dawley, Wistar and Wistar Lewis rats thirty-five days after the section of one sciatic nerve. As expected, autotomy developed in Sprague Dawley and Wistar, but not in Wistar Lewis rats. In the Wistar Lewis, brain and spinal cord concentrations of Met-enkephalin increased, beta-endorphin concentrations were unchanged. In Wistar and Sprague Dawley rats the increase of Met-enkephalin was accompanied by a decrease of beta-endorphin. Administration of chlomipramine, a drug usually employed in the treatment of deafferentation pain, normalized the concentrations of beta-endorphin in the Sprague Dawley and Wistar rats, and avoided the development of autotomy, while Met-enkephalin concentrations did never change. The data presented suggest a possible correlation between beta-endorphin and autotomy.
AB - Autotomy and the concentrations of beta-endorphin and Met-enkephalin in brain areas and the spinal cord were measured in Sprague Dawley, Wistar and Wistar Lewis rats thirty-five days after the section of one sciatic nerve. As expected, autotomy developed in Sprague Dawley and Wistar, but not in Wistar Lewis rats. In the Wistar Lewis, brain and spinal cord concentrations of Met-enkephalin increased, beta-endorphin concentrations were unchanged. In Wistar and Sprague Dawley rats the increase of Met-enkephalin was accompanied by a decrease of beta-endorphin. Administration of chlomipramine, a drug usually employed in the treatment of deafferentation pain, normalized the concentrations of beta-endorphin in the Sprague Dawley and Wistar rats, and avoided the development of autotomy, while Met-enkephalin concentrations did never change. The data presented suggest a possible correlation between beta-endorphin and autotomy.
KW - Autotomy
KW - Beta-endorphin
KW - Chlomipramine
KW - Deafferentation
KW - Met-enkephalin
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U2 - 10.1016/0091-3057(87)90458-8
DO - 10.1016/0091-3057(87)90458-8
M3 - Article
C2 - 2960988
AN - SCOPUS:0023506092
VL - 28
SP - 385
EP - 388
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - 3
ER -