Auxological and metabolic study in small for gestational age children during 2 years follow-up

Paola Polo Perucchin, Cristina Traggiai, Maria Grazia Calevo, Roberto Gastaldi, Eliana Di Battista, Alice Amisano, Renata Lorini

Research output: Contribution to journalArticle

Abstract

Objective. To compare auxological and metabolic status of preterm (PT) and fullterm (FT) small for gestational age (SGA) babies from birth until age 2 years and to study the role of intrauterine growth retardation (IUGR) in auxological and metabolic outcome in SGA babies. Methods. We enrolled 44 SGA babies (22 FTs, 22 PTs) followed up six monthly. Anthropometric and metabolic measurements (fasting glucose, basal insulin level, total-cholesterol, triglycerides) were performed. HOMA-IR was selected to assess insulin sensitivity. Results. Both FTs and PTs from birth to age 6 months showed a significant increase in weight and length; the weight gain decreased from 6 to 12 months only in PTs. At 24 months, we observed catch-up growth in 90% of FTs and 87% of PTs. Insulinemia and HOMA-IR decreased from birth to 24 months, in particular between 6 and 12 months. PTs SGA with IUGR were significantly smaller than FTs SGA without IUGR (p=0.01) and showed a lower length growth velocity. Moreover they showed also higher insulin levels and HOMA-IR at birth; these values decreased at 12 and 24 months. Conclusions. Our study showed no significant difference between PTs and FTs SGA in auxological and metabolic parameters. However, prematurity with IUGR proved to be a significant factor that should be considered in the timing of auxological follow-up of SGA subjects.

Original languageEnglish
Pages (from-to)381-387
Number of pages7
JournalJournal of Maternal-Fetal and Neonatal Medicine
Volume24
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • catch up growth
  • insulin resistance
  • intrauterine growth retardation
  • preterm babies
  • Small for gestational age babies

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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