Avoidance facilitation in adult mice by prenatal administration of the nootropic drug oxiracetam

Martine Ammassari-Teule, Francesca R. D'Amato, Mario Sansone, Alberto Oliverio

Research output: Contribution to journalArticlepeer-review

Abstract

CD-1 mice prenatally exposed to saline solution or to the nootropic drug oxiracetam (50 mg/Kg during the whole pregnancy) were tested, when adults, for locomotor activity and for shuttle-box avoidance acquisition. Prenatal drug exposure produced long-lasting effects, evident in mature offspring. At the age of two months, mice prenatally exposed to oxiracetam showed a slight but significant reduction in locomotor activity. At the age of three months, these animals exhibited higher performances than control mice in avoidance acquisition.

Original languageEnglish
Pages (from-to)1169-1176
Number of pages8
JournalPharmacological Research Communications
Volume18
Issue number12
DOIs
Publication statusPublished - 1986

ASJC Scopus subject areas

  • Pharmacology

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