Axial myoclonus in paraproteinemic polyneuropathy

Roberto Vetrugno, Rocco Liguori, Roberto D'Alessandro, Roberto D'Angelo, Maria Alessandria, Pasquale Montagna

Research output: Contribution to journalArticlepeer-review

Abstract

We describe a patient with a paraproteinemic anti-myelin-associated glycoprotein (anti-MAG) antibody polyneuropathy and concomitant axial myoclonic jerks. Neurophysiological investigation revealed that axial jerks were asymmetrical and exaggerated by lying in bed. They disappeared during mental arousal and sleep. Analysis of axial myoclonus showed that the first activated muscle was the left rectus abdominis with subsequent rostral and caudal propagation of a propriospinal type. Plasmapheresis substantially reduced the frequency and intensity of axial myoclonic jerks. In our patient, propriospinal myoclonus was associated with anti-MAG polyneuropathy, but the causal relationship remains unclear.

Original languageEnglish
Pages (from-to)1330-1335
Number of pages6
JournalMuscle and Nerve
Volume38
Issue number4
DOIs
Publication statusPublished - Oct 2008

Keywords

  • Anti-MAG antibody
  • Polyneuropathy
  • Posture
  • Propriospinal myoclonus
  • Sleep

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology

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