Axillary lymph node metastases detection with 99mTc-sestamibi scintimammography in patients with breast cancer undergoing curative surgery

Franco Lumachi, Guido Ferretti, Michele Povolato, Franco Bui, Diego Cecchin, Maria Cristina Marzola, Pietro Zucchetta, Umberto Basso

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Axillary lymph node (AN) status is the primary prognostic discriminant in patients with breast cancer (BC). Although axillary dissection represents the method of choice for obtaining such information, less invasive procedures have been suggested. The aim of this study was to evaluate the usefulness of 99mTc-sestamibi scintimammography (SSM) in detecting AN involvement in patients with confirmed primary BC undergoing surgery. Patients and Methods: A series of 159 consecutive women (median age 54 years, range 36-78 years) with confirmed BC undergoing curative surgery were enrolled in the study. Each patient underwent SSM, from 4 to 12 days prior to surgery. According to the tumour staging, modified radical mastectomy was performed in 41 (25.8%) patients, while 118 (74.2%) patients underwent breast conserving surgery with dissection of the axilla. The results of SSM were compared against the final histological evaluation of the axillary nodes. Results: The final pathology showed 33 (20.8%) pT1b, 90 (56.6%) pT1c, and 36 (22.6%) pT2 breast carcinomas. The greatest diameter of the tumour ranged from 8 to 30 mm (median 16 mm). Sixty patients (37.7%) had axillary node metastases (N1), and 99 (60.3%) had negative nodes (N0). The age of the patients significantly correlated with both size of the tumour (R=0.24, p

Original languageEnglish
Pages (from-to)2949-2952
Number of pages4
JournalAnticancer Research
Volume27
Issue number4 C
Publication statusPublished - Jul 2007

Keywords

  • Axillary node metastases
  • Breast cancer
  • Scintimammography

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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