Abstract
Original language | English |
---|---|
Pages (from-to) | 400-407 |
Number of pages | 8 |
Journal | Minerva Chir. |
Volume | 75 |
Issue number | 6 |
DOIs | |
Publication status | Published - 2020 |
Keywords
- Adjuvant
- Axilla
- Breast neoplasms
- Chemotherapy
- Sentinel lymph node biopsy
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Axillary management after neoadjuvant treatment : Minerva Chirurgica. / Montagna, G.; Corso, G.; Di Micco, R.; van Den Rul, N.; Rocco, N.
In: Minerva Chir., Vol. 75, No. 6, 2020, p. 400-407.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Axillary management after neoadjuvant treatment
T2 - Minerva Chirurgica
AU - Montagna, G.
AU - Corso, G.
AU - Di Micco, R.
AU - van Den Rul, N.
AU - Rocco, N.
N1 - Export Date: 17 March 2021 CODEN: MICHA Correspondence Address: Montagna, G.; Breast Unit, United States; email: montagng@mskcc.org References: King, TA, Morrow, M., Surgical issues in patients with breast cancer receiving neoadjuvant chemotherapy (2015) Nat Rev Clin Oncol, 12, pp. 335-343; Gralow, JR, Burstein, HJ, Wood, W, Hortobagyi, GN, Gianni, L, von Minckwitz, G, Preoperative therapy in invasive breast cancer: pathologic assessment and systemic therapy issues in operable disease (2008) J Clin Oncol, 26, pp. 814-819; Burstein, HJ, Curigliano, G, Loibl, S, Dubsky, P, Gnant, M, Poortmans, P, Estimating the benefits of therapy for early-stage breast cancer: the St. Gallen International Consensus Guidelines for the primary therapy of early breast cancer 2019 (2019) Ann Oncol, 30, pp. 1541-1557. , Members of the St. Gallen International Consensus Panel on the Primary Therapy of Early Breast Cancer 2019; Fisher, B, Bryant, J, Wolmark, N, Mamounas, E, Brown, A, Fisher, ER, Effect of preoperative chemotherapy on the outcome of women with operable breast cancer (1998) J Clin Oncol, 16, pp. 2672-2685; Mieog, JS, van der Hage, JA, van de Velde, CJ., Neoadjuvant chemotherapy for operable breast cancer (2007) Br J Surg, 94, pp. 1189-1200; Petruolo, O, Sevilimedu, V, Montagna, G, Le, T, Morrow, M, Barrio, AV., How Often Does Modern Neoadjuvant Chemotherapy Downstage Patients to Breast-Conserving Surgery? 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PY - 2020
Y1 - 2020
N2 - Since its introduction nearly 30 years ago, sentinel lymph node biopsy (SLNB) has become the standard technique to stage the axilla for the great majority of patients with early breast cancer. While the accuracy of SLNB in clinically nodenegative patients who undergo neoadjuvant chemotherapy (NAC) is similar to the upfront surgery setting, modifications of the technique to improve the false negative rate are necessary in node-positive patients at presentation. Currently, patients who present with matted nodes, cN1 patients who fail to downstage to cN0 with NAC and those with pathological residual disease have an indication to undergo axillary lymph node dissection. Ongoing trials will confirm if extensive nodal irradiation can replace surgery in patients with residual nodal disease after NAC and if nodal radiotherapy can be omitted in patients who achieve nodal pathological complete response. The aim of this review was to focus on the open questions on the management of the axilla after NAC. © 2020 Edizioni Minerva Medica. All rights reserved.
AB - Since its introduction nearly 30 years ago, sentinel lymph node biopsy (SLNB) has become the standard technique to stage the axilla for the great majority of patients with early breast cancer. While the accuracy of SLNB in clinically nodenegative patients who undergo neoadjuvant chemotherapy (NAC) is similar to the upfront surgery setting, modifications of the technique to improve the false negative rate are necessary in node-positive patients at presentation. Currently, patients who present with matted nodes, cN1 patients who fail to downstage to cN0 with NAC and those with pathological residual disease have an indication to undergo axillary lymph node dissection. Ongoing trials will confirm if extensive nodal irradiation can replace surgery in patients with residual nodal disease after NAC and if nodal radiotherapy can be omitted in patients who achieve nodal pathological complete response. The aim of this review was to focus on the open questions on the management of the axilla after NAC. © 2020 Edizioni Minerva Medica. All rights reserved.
KW - Adjuvant
KW - Axilla
KW - Breast neoplasms
KW - Chemotherapy
KW - Sentinel lymph node biopsy
U2 - 10.23736/S0026-4733.20.08600-9
DO - 10.23736/S0026-4733.20.08600-9
M3 - Article
VL - 75
SP - 400
EP - 407
JO - Minerva Chir.
JF - Minerva Chir.
SN - 0026-4733
IS - 6
ER -