Axillary metastases in breast cancer patients with negative sentinel nodes

A follow-up of 3548 cases

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78 Citations (Scopus)

Abstract

Premises: Sentinel node biopsy (SNB) in patients with breast carcinoma accurately predicts the axillary node status. However, in some 4-7% of patients with negative sentinel nodes, the remaining axillary nodes harbour cancer cells. Objective: Our purpose was the long-term observation of a large number of patients who did not receive axillary dissection after a negative sentinel node biopsy, in order to evaluate the incidence of overt axillary metastases. Methods: Patients (3548) treated from 1996 to 2004, with negative sentinel nodes not submitted to axillary dissection, were followed up to 11 years with a median follow-up of 48 months. Results: Three hundred and sixteen unfavourable events occurred among the 3548 patients, 196 of which (5.5%) related to primary breast carcinoma. Thirty one cases of overt axillary metastases were found (0.9%): they received total axillary dissection and 27 of them are at present alive and well. The 5-year overall survival rate of the whole series was 98%. Conclusions: Patients with negative sentinel node biopsy not submitted to axillary dissection show, at follow-up, a rate of overt axillary metastases lower than expected.

Original languageEnglish
Pages (from-to)1381-1388
Number of pages8
JournalEuropean Journal of Cancer
Volume45
Issue number8
DOIs
Publication statusPublished - May 2009

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Breast Neoplasms
Neoplasm Metastasis
Dissection
Biopsy
cyhalothrin
Survival Rate
Observation
Incidence
Neoplasms

Keywords

  • Breast cancer
  • Negative sentinel node biopsy
  • Overt axillary metastases

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

@article{c2a4f77b7fbc4a1788690eb1010317ab,
title = "Axillary metastases in breast cancer patients with negative sentinel nodes: A follow-up of 3548 cases",
abstract = "Premises: Sentinel node biopsy (SNB) in patients with breast carcinoma accurately predicts the axillary node status. However, in some 4-7{\%} of patients with negative sentinel nodes, the remaining axillary nodes harbour cancer cells. Objective: Our purpose was the long-term observation of a large number of patients who did not receive axillary dissection after a negative sentinel node biopsy, in order to evaluate the incidence of overt axillary metastases. Methods: Patients (3548) treated from 1996 to 2004, with negative sentinel nodes not submitted to axillary dissection, were followed up to 11 years with a median follow-up of 48 months. Results: Three hundred and sixteen unfavourable events occurred among the 3548 patients, 196 of which (5.5{\%}) related to primary breast carcinoma. Thirty one cases of overt axillary metastases were found (0.9{\%}): they received total axillary dissection and 27 of them are at present alive and well. The 5-year overall survival rate of the whole series was 98{\%}. Conclusions: Patients with negative sentinel node biopsy not submitted to axillary dissection show, at follow-up, a rate of overt axillary metastases lower than expected.",
keywords = "Breast cancer, Negative sentinel node biopsy, Overt axillary metastases",
author = "Umberto Veronesi and Viviana Galimberti and Giovanni Paganelli and Patrick Maisonneuve and Giuseppe Viale and Roberto Orecchia and Alberto Luini and Mattia Intra and Paolo Veronesi and Pietro Caldarella and Giuseppe Renne and Nicole Rotmensz and Claudia Sangalli and {De Brito Lima}, Luciana and Marco Tullii and Stefano Zurrida",
year = "2009",
month = "5",
doi = "10.1016/j.ejca.2008.11.041",
language = "English",
volume = "45",
pages = "1381--1388",
journal = "European Journal of Cancer",
issn = "0959-8049",
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TY - JOUR

T1 - Axillary metastases in breast cancer patients with negative sentinel nodes

T2 - A follow-up of 3548 cases

AU - Veronesi, Umberto

AU - Galimberti, Viviana

AU - Paganelli, Giovanni

AU - Maisonneuve, Patrick

AU - Viale, Giuseppe

AU - Orecchia, Roberto

AU - Luini, Alberto

AU - Intra, Mattia

AU - Veronesi, Paolo

AU - Caldarella, Pietro

AU - Renne, Giuseppe

AU - Rotmensz, Nicole

AU - Sangalli, Claudia

AU - De Brito Lima, Luciana

AU - Tullii, Marco

AU - Zurrida, Stefano

PY - 2009/5

Y1 - 2009/5

N2 - Premises: Sentinel node biopsy (SNB) in patients with breast carcinoma accurately predicts the axillary node status. However, in some 4-7% of patients with negative sentinel nodes, the remaining axillary nodes harbour cancer cells. Objective: Our purpose was the long-term observation of a large number of patients who did not receive axillary dissection after a negative sentinel node biopsy, in order to evaluate the incidence of overt axillary metastases. Methods: Patients (3548) treated from 1996 to 2004, with negative sentinel nodes not submitted to axillary dissection, were followed up to 11 years with a median follow-up of 48 months. Results: Three hundred and sixteen unfavourable events occurred among the 3548 patients, 196 of which (5.5%) related to primary breast carcinoma. Thirty one cases of overt axillary metastases were found (0.9%): they received total axillary dissection and 27 of them are at present alive and well. The 5-year overall survival rate of the whole series was 98%. Conclusions: Patients with negative sentinel node biopsy not submitted to axillary dissection show, at follow-up, a rate of overt axillary metastases lower than expected.

AB - Premises: Sentinel node biopsy (SNB) in patients with breast carcinoma accurately predicts the axillary node status. However, in some 4-7% of patients with negative sentinel nodes, the remaining axillary nodes harbour cancer cells. Objective: Our purpose was the long-term observation of a large number of patients who did not receive axillary dissection after a negative sentinel node biopsy, in order to evaluate the incidence of overt axillary metastases. Methods: Patients (3548) treated from 1996 to 2004, with negative sentinel nodes not submitted to axillary dissection, were followed up to 11 years with a median follow-up of 48 months. Results: Three hundred and sixteen unfavourable events occurred among the 3548 patients, 196 of which (5.5%) related to primary breast carcinoma. Thirty one cases of overt axillary metastases were found (0.9%): they received total axillary dissection and 27 of them are at present alive and well. The 5-year overall survival rate of the whole series was 98%. Conclusions: Patients with negative sentinel node biopsy not submitted to axillary dissection show, at follow-up, a rate of overt axillary metastases lower than expected.

KW - Breast cancer

KW - Negative sentinel node biopsy

KW - Overt axillary metastases

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