Axillary recurrence after negative sentinel lymph node biopsy without axillary dissection: A study on 479 breast cancer patients

Giorgio Zavagno, P. Carcoforo, Z. Franchini, M. Renier, L. Barutta, G. L. De Salvo, K. Maravegias, G. Capitanio, D. Nitti, M. Lise

Research output: Contribution to journalArticle

52 Citations (Scopus)

Abstract

Aims: To determine the axillary recurrence rate in breast cancer patients with negative sentinel lymph nodes (SLN) who did not undergo further axillary lymph node dissection (ALND), and to establish whether this conservative axillary approach leads to an increased recourse to diagnostic axillary biopsy during the follow-up period because of the clinical suspicion of nodal recurrence. Methods: In 479 patients, operated on for early breast cancer between 1998 and 2002 in five institutions, SLN biopsy was negative and no further axillary surgery was performed. SLN was localized using subdermal injection with 30-50 MBq of 99m-Tc-colloidal albumin. Follow-up controls were performed at 6-monthly intervals. Results: The mean number of SLNs removed was 1.4 per patient. Most patients (90.6%) were given adjuvant systemic therapy, based on the primary tumour characteristics. At a median follow-up of 35.8 months, no clinical axillary recurrence was found. No patient underwent surgical axillary biopsy for suspicious clinical or ultrasonographic findings. Conclusions: Our results confirm that SLN biopsy without ALND in SLN-negative patients with early breast cancer is not followed by clinically evident axillary recurrence in the short-term.

Original languageEnglish
Pages (from-to)715-720
Number of pages6
JournalEuropean Journal of Surgical Oncology
Volume31
Issue number7
DOIs
Publication statusPublished - Sep 2005

Fingerprint

Sentinel Lymph Node Biopsy
Dissection
Breast Neoplasms
Recurrence
Lymph Node Excision
Technetium Tc 99m Aggregated Albumin
Biopsy
Injections
Sentinel Lymph Node
Neoplasms

Keywords

  • Axillary lymph node dissection
  • Breast cancer
  • Nodal recurrence
  • Sentinel lymph node

ASJC Scopus subject areas

  • Oncology
  • Surgery

Cite this

Axillary recurrence after negative sentinel lymph node biopsy without axillary dissection : A study on 479 breast cancer patients. / Zavagno, Giorgio; Carcoforo, P.; Franchini, Z.; Renier, M.; Barutta, L.; De Salvo, G. L.; Maravegias, K.; Capitanio, G.; Nitti, D.; Lise, M.

In: European Journal of Surgical Oncology, Vol. 31, No. 7, 09.2005, p. 715-720.

Research output: Contribution to journalArticle

Zavagno, G, Carcoforo, P, Franchini, Z, Renier, M, Barutta, L, De Salvo, GL, Maravegias, K, Capitanio, G, Nitti, D & Lise, M 2005, 'Axillary recurrence after negative sentinel lymph node biopsy without axillary dissection: A study on 479 breast cancer patients', European Journal of Surgical Oncology, vol. 31, no. 7, pp. 715-720. https://doi.org/10.1016/j.ejso.2005.04.006
Zavagno, Giorgio ; Carcoforo, P. ; Franchini, Z. ; Renier, M. ; Barutta, L. ; De Salvo, G. L. ; Maravegias, K. ; Capitanio, G. ; Nitti, D. ; Lise, M. / Axillary recurrence after negative sentinel lymph node biopsy without axillary dissection : A study on 479 breast cancer patients. In: European Journal of Surgical Oncology. 2005 ; Vol. 31, No. 7. pp. 715-720.
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T1 - Axillary recurrence after negative sentinel lymph node biopsy without axillary dissection

T2 - A study on 479 breast cancer patients

AU - Zavagno, Giorgio

AU - Carcoforo, P.

AU - Franchini, Z.

AU - Renier, M.

AU - Barutta, L.

AU - De Salvo, G. L.

AU - Maravegias, K.

AU - Capitanio, G.

AU - Nitti, D.

AU - Lise, M.

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N2 - Aims: To determine the axillary recurrence rate in breast cancer patients with negative sentinel lymph nodes (SLN) who did not undergo further axillary lymph node dissection (ALND), and to establish whether this conservative axillary approach leads to an increased recourse to diagnostic axillary biopsy during the follow-up period because of the clinical suspicion of nodal recurrence. Methods: In 479 patients, operated on for early breast cancer between 1998 and 2002 in five institutions, SLN biopsy was negative and no further axillary surgery was performed. SLN was localized using subdermal injection with 30-50 MBq of 99m-Tc-colloidal albumin. Follow-up controls were performed at 6-monthly intervals. Results: The mean number of SLNs removed was 1.4 per patient. Most patients (90.6%) were given adjuvant systemic therapy, based on the primary tumour characteristics. At a median follow-up of 35.8 months, no clinical axillary recurrence was found. No patient underwent surgical axillary biopsy for suspicious clinical or ultrasonographic findings. Conclusions: Our results confirm that SLN biopsy without ALND in SLN-negative patients with early breast cancer is not followed by clinically evident axillary recurrence in the short-term.

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KW - Axillary lymph node dissection

KW - Breast cancer

KW - Nodal recurrence

KW - Sentinel lymph node

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