Axillary ultrasound and Fine-Needle Aspiration Cytology in the preoperative staging of axillary node metastasis in breast cancer patients

Marco Gipponi, Piero Fregatti, Alessandro Garlaschi, Federica Murelli, Cecilia Margarino, Francesca Depaoli, Paola Baccini, Maurizio Gallo, Daniele Friedman

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Objective A prospective observational clinical study was undertaken to assess the accuracy of preoperative Axillary Ultrasound (AUS) plus Fine-Needle Aspiration Cytology (FNAC) as well as and its clinical utility, that is the capacity of the information supplied by the test to guide the clinical decision-making. Materials and methods from January 2013 to August 2015, 400 female patients with pT1-3 cN0 operable breast cancer underwent AUS with FNAC at the Breast Unit of the “IRCCS San Martino-IST” in Genoa (Italy). Results 127 out of 400 patients (31.7%) had axillary lymph node metastases; in 69 out of 127 node-positive patients (54.3%) AUS detected at least one abnormal lymph node, and in 56 out of 127 patients (44.1%) the abnormal sonographic pattern of the lymph node was coupled with a positive FNAC finding. No false-positive finding by both AUS-alone or combined AUS/FNAC was observed. AUS-alone had sensitivity of 54.3% (69/127), specificity of 100% (273/273), PPV of 100% (69/69), NPV of 82.5% (273/331), and accuracy of 85.5% (342/400). Combined AUS/FNAC had sensitivity of 44.1% (56/127), specificity of 100% (273/273), PPV of 100% (56/56), NPV of 79.4% (273/344), and accuracy of 82.2% (329/400). Conclusions AUS-alone or combined AUS/FNAC had a high accuracy rate coupled with a more than satisfactory efficiency due to their low costs and easy access for the preoperative staging of the axilla. Notably, AUS-alone might be suggested for the preoperative staging of patients with early stage breast cancer because FNAC did not increased the specificity but reduced the sensitivity of the technique. Patients with negative findings might undergo either SLNB or close observation while waiting for the definitive results of ongoing SOUND randomized clinical trial.

Original languageEnglish
Pages (from-to)146-150
Number of pages5
JournalBreast
Volume30
DOIs
Publication statusPublished - Dec 1 2016

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Fine Needle Biopsy
Cell Biology
Breast Neoplasms
Neoplasm Metastasis
Lymph Nodes
Axilla
Italy
Observational Studies
Breast
Randomized Controlled Trials
Observation
Costs and Cost Analysis
Sensitivity and Specificity

Keywords

  • Breast cancer
  • Sentinel lymph node
  • Staging

ASJC Scopus subject areas

  • Surgery

Cite this

Axillary ultrasound and Fine-Needle Aspiration Cytology in the preoperative staging of axillary node metastasis in breast cancer patients. / Gipponi, Marco; Fregatti, Piero; Garlaschi, Alessandro; Murelli, Federica; Margarino, Cecilia; Depaoli, Francesca; Baccini, Paola; Gallo, Maurizio; Friedman, Daniele.

In: Breast, Vol. 30, 01.12.2016, p. 146-150.

Research output: Contribution to journalArticle

Gipponi, Marco ; Fregatti, Piero ; Garlaschi, Alessandro ; Murelli, Federica ; Margarino, Cecilia ; Depaoli, Francesca ; Baccini, Paola ; Gallo, Maurizio ; Friedman, Daniele. / Axillary ultrasound and Fine-Needle Aspiration Cytology in the preoperative staging of axillary node metastasis in breast cancer patients. In: Breast. 2016 ; Vol. 30. pp. 146-150.
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title = "Axillary ultrasound and Fine-Needle Aspiration Cytology in the preoperative staging of axillary node metastasis in breast cancer patients",
abstract = "Objective A prospective observational clinical study was undertaken to assess the accuracy of preoperative Axillary Ultrasound (AUS) plus Fine-Needle Aspiration Cytology (FNAC) as well as and its clinical utility, that is the capacity of the information supplied by the test to guide the clinical decision-making. Materials and methods from January 2013 to August 2015, 400 female patients with pT1-3 cN0 operable breast cancer underwent AUS with FNAC at the Breast Unit of the “IRCCS San Martino-IST” in Genoa (Italy). Results 127 out of 400 patients (31.7{\%}) had axillary lymph node metastases; in 69 out of 127 node-positive patients (54.3{\%}) AUS detected at least one abnormal lymph node, and in 56 out of 127 patients (44.1{\%}) the abnormal sonographic pattern of the lymph node was coupled with a positive FNAC finding. No false-positive finding by both AUS-alone or combined AUS/FNAC was observed. AUS-alone had sensitivity of 54.3{\%} (69/127), specificity of 100{\%} (273/273), PPV of 100{\%} (69/69), NPV of 82.5{\%} (273/331), and accuracy of 85.5{\%} (342/400). Combined AUS/FNAC had sensitivity of 44.1{\%} (56/127), specificity of 100{\%} (273/273), PPV of 100{\%} (56/56), NPV of 79.4{\%} (273/344), and accuracy of 82.2{\%} (329/400). Conclusions AUS-alone or combined AUS/FNAC had a high accuracy rate coupled with a more than satisfactory efficiency due to their low costs and easy access for the preoperative staging of the axilla. Notably, AUS-alone might be suggested for the preoperative staging of patients with early stage breast cancer because FNAC did not increased the specificity but reduced the sensitivity of the technique. Patients with negative findings might undergo either SLNB or close observation while waiting for the definitive results of ongoing SOUND randomized clinical trial.",
keywords = "Breast cancer, Sentinel lymph node, Staging",
author = "Marco Gipponi and Piero Fregatti and Alessandro Garlaschi and Federica Murelli and Cecilia Margarino and Francesca Depaoli and Paola Baccini and Maurizio Gallo and Daniele Friedman",
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T1 - Axillary ultrasound and Fine-Needle Aspiration Cytology in the preoperative staging of axillary node metastasis in breast cancer patients

AU - Gipponi, Marco

AU - Fregatti, Piero

AU - Garlaschi, Alessandro

AU - Murelli, Federica

AU - Margarino, Cecilia

AU - Depaoli, Francesca

AU - Baccini, Paola

AU - Gallo, Maurizio

AU - Friedman, Daniele

PY - 2016/12/1

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N2 - Objective A prospective observational clinical study was undertaken to assess the accuracy of preoperative Axillary Ultrasound (AUS) plus Fine-Needle Aspiration Cytology (FNAC) as well as and its clinical utility, that is the capacity of the information supplied by the test to guide the clinical decision-making. Materials and methods from January 2013 to August 2015, 400 female patients with pT1-3 cN0 operable breast cancer underwent AUS with FNAC at the Breast Unit of the “IRCCS San Martino-IST” in Genoa (Italy). Results 127 out of 400 patients (31.7%) had axillary lymph node metastases; in 69 out of 127 node-positive patients (54.3%) AUS detected at least one abnormal lymph node, and in 56 out of 127 patients (44.1%) the abnormal sonographic pattern of the lymph node was coupled with a positive FNAC finding. No false-positive finding by both AUS-alone or combined AUS/FNAC was observed. AUS-alone had sensitivity of 54.3% (69/127), specificity of 100% (273/273), PPV of 100% (69/69), NPV of 82.5% (273/331), and accuracy of 85.5% (342/400). Combined AUS/FNAC had sensitivity of 44.1% (56/127), specificity of 100% (273/273), PPV of 100% (56/56), NPV of 79.4% (273/344), and accuracy of 82.2% (329/400). Conclusions AUS-alone or combined AUS/FNAC had a high accuracy rate coupled with a more than satisfactory efficiency due to their low costs and easy access for the preoperative staging of the axilla. Notably, AUS-alone might be suggested for the preoperative staging of patients with early stage breast cancer because FNAC did not increased the specificity but reduced the sensitivity of the technique. Patients with negative findings might undergo either SLNB or close observation while waiting for the definitive results of ongoing SOUND randomized clinical trial.

AB - Objective A prospective observational clinical study was undertaken to assess the accuracy of preoperative Axillary Ultrasound (AUS) plus Fine-Needle Aspiration Cytology (FNAC) as well as and its clinical utility, that is the capacity of the information supplied by the test to guide the clinical decision-making. Materials and methods from January 2013 to August 2015, 400 female patients with pT1-3 cN0 operable breast cancer underwent AUS with FNAC at the Breast Unit of the “IRCCS San Martino-IST” in Genoa (Italy). Results 127 out of 400 patients (31.7%) had axillary lymph node metastases; in 69 out of 127 node-positive patients (54.3%) AUS detected at least one abnormal lymph node, and in 56 out of 127 patients (44.1%) the abnormal sonographic pattern of the lymph node was coupled with a positive FNAC finding. No false-positive finding by both AUS-alone or combined AUS/FNAC was observed. AUS-alone had sensitivity of 54.3% (69/127), specificity of 100% (273/273), PPV of 100% (69/69), NPV of 82.5% (273/331), and accuracy of 85.5% (342/400). Combined AUS/FNAC had sensitivity of 44.1% (56/127), specificity of 100% (273/273), PPV of 100% (56/56), NPV of 79.4% (273/344), and accuracy of 82.2% (329/400). Conclusions AUS-alone or combined AUS/FNAC had a high accuracy rate coupled with a more than satisfactory efficiency due to their low costs and easy access for the preoperative staging of the axilla. Notably, AUS-alone might be suggested for the preoperative staging of patients with early stage breast cancer because FNAC did not increased the specificity but reduced the sensitivity of the technique. Patients with negative findings might undergo either SLNB or close observation while waiting for the definitive results of ongoing SOUND randomized clinical trial.

KW - Breast cancer

KW - Sentinel lymph node

KW - Staging

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