Axon-somatic back-propagation in detailed models of spinal alpha motoneurons

Pietro Balbi, Sergio Martinoia, Paolo Massobrio

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Antidromic action potentials following distal stimulation of motor axons occasionally fail to invade the soma of alpha motoneurons in spinal cord, due to their passing through regions of high non-uniformity. Morphologically detailed conductance-based models of cat spinal alpha motoneurons have been developed, with the aim to reproduce and clarify some aspects of the electrophysiological behavior of the antidromic axon-somatic spike propagation. Fourteen 3D morphologically detailed somata and dendrites of cat spinal alpha motoneurons have been imported from an open-access web-based database of neuronal morphologies, NeuroMorpho.org, and instantiated in neurocomputational models. An axon hillock, an axonal initial segment and a myelinated axon are added to each model. By sweeping the diameter of the axonal initial segment (AIS) and the axon hillock, as well as the maximal conductances of sodium channels at the AIS and at the soma, the developed models are able to show the relationships between different geometric and electrophysiological configurations and the voltage attenuation of the antidromically traveling wave. In particular, a greater than usually admitted sodium conductance at AIS is necessary and sufficient to overcome the dramatic voltage attenuation occurring during antidromic spike propagation both at the myelinated axon-AIS and at the AIS-soma transitions.

Original languageEnglish
Article number15
JournalFrontiers in Computational Neuroscience
Volume9
Issue numberJAN
DOIs
Publication statusPublished - Feb 12 2015

Fingerprint

Carisoprodol
Motor Neurons
Axons
Cats
Sodium Channels
Dendrites
Action Potentials
Spinal Cord
Sodium
Databases
Axon Initial Segment

Keywords

  • Axonal initial segment
  • Back-propagation
  • Detailed model
  • Sodium channel density
  • Spinal motoneuron

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience

Cite this

Axon-somatic back-propagation in detailed models of spinal alpha motoneurons. / Balbi, Pietro; Martinoia, Sergio; Massobrio, Paolo.

In: Frontiers in Computational Neuroscience, Vol. 9, No. JAN, 15, 12.02.2015.

Research output: Contribution to journalArticle

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