Axonal Na+ channels ensure fast spike activation and back-propagation in cerebellar granule cells

Shyam Diwakar, Jacopo Magistretti, Mitchell Goldfarb, Giovanni Naldi, Egidio D'Angelo

Research output: Contribution to journalArticle

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Abstract

In most neurons, Na+ channels in the axon are complemented by others localized in the soma and dendrites to ensure spike back-propagation. However, cerebellar granule cells are neurons with simplified architecture in which the dendrites are short and unbranched and a single thin ascending axon travels toward the molecular layer before bifurcating into parallel fibers. Here we show that in cerebellar granule cells, Na+ channels are enriched in the axon, especially in the hillock, but almost absent from soma and dendrites. The impact of this channel distribution on neuronal electroresponsiveness was investigated by multi-compartmental modeling. Numerical simulations indicated that granule cells have a compact electrotonic structure allowing excitatory postsynaptic potentials to diffuse with little attenuation from dendrites to axon. The spike arose almost simultaneously along the whole axonal ascending branch and invaded the hillock the activation of which promoted spike back-propagation with marginal delay (

Original languageEnglish
Pages (from-to)519-532
Number of pages14
JournalJournal of Neurophysiology
Volume101
Issue number2
DOIs
Publication statusPublished - Feb 2009

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Dendrites
Axons
Carisoprodol
Neurons
Excitatory Postsynaptic Potentials

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

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Axonal Na+ channels ensure fast spike activation and back-propagation in cerebellar granule cells. / Diwakar, Shyam; Magistretti, Jacopo; Goldfarb, Mitchell; Naldi, Giovanni; D'Angelo, Egidio.

In: Journal of Neurophysiology, Vol. 101, No. 2, 02.2009, p. 519-532.

Research output: Contribution to journalArticle

Diwakar, Shyam ; Magistretti, Jacopo ; Goldfarb, Mitchell ; Naldi, Giovanni ; D'Angelo, Egidio. / Axonal Na+ channels ensure fast spike activation and back-propagation in cerebellar granule cells. In: Journal of Neurophysiology. 2009 ; Vol. 101, No. 2. pp. 519-532.
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