Axonal neuropathy associated with interferon-α treatment for hepatitis C: HLA-DR immunoreactivity in Schwann cells

A. Quattrini, C. Comi, R. Nemni, V. Martinelli, A. Villa, M. Caimi, L. Wrabetz, N. Canal

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A 44-year-old man developed a peripheral neuropathy during treatment with interferon-α for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.

Original languageEnglish
Pages (from-to)504-508
Number of pages5
JournalActa Neuropathologica
Volume94
Issue number5
DOIs
Publication statusPublished - 1997

Fingerprint

Sural Nerve
Paresthesia
Schwann Cells
HLA-DR Antigens
Peripheral Nervous System Diseases
Chronic Hepatitis C
Hepatitis C
Interferons
Fluorescent Antibody Technique
Hand
Biopsy
Therapeutics

Keywords

  • Hepatitis C
  • HLA-DR antigens
  • Interferon-α
  • Neuropathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Axonal neuropathy associated with interferon-α treatment for hepatitis C : HLA-DR immunoreactivity in Schwann cells. / Quattrini, A.; Comi, C.; Nemni, R.; Martinelli, V.; Villa, A.; Caimi, M.; Wrabetz, L.; Canal, N.

In: Acta Neuropathologica, Vol. 94, No. 5, 1997, p. 504-508.

Research output: Contribution to journalArticle

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