Axonal neuropathy associated with interferon-α treatment for hepatitis C: HLA-DR immunoreactivity in Schwann cells

A. Quattrini, C. Comi, R. Nemni, V. Martinelli, A. Villa, M. Caimi, L. Wrabetz, N. Canal

Research output: Contribution to journalArticle

Abstract

A 44-year-old man developed a peripheral neuropathy during treatment with interferon-α for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.

Original languageEnglish
Pages (from-to)504-508
Number of pages5
JournalActa Neuropathologica
Volume94
Issue number5
DOIs
Publication statusPublished - 1997

Keywords

  • Hepatitis C
  • HLA-DR antigens
  • Interferon-α
  • Neuropathy

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

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