Abstract
A 44-year-old man developed a peripheral neuropathy during treatment with interferon-α for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.
| Original language | English |
|---|---|
| Pages (from-to) | 504-508 |
| Number of pages | 5 |
| Journal | Acta Neuropathologica |
| Volume | 94 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1997 |
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Keywords
- Hepatitis C
- HLA-DR antigens
- Interferon-α
- Neuropathy
ASJC Scopus subject areas
- Clinical Neurology
- Pathology and Forensic Medicine
- Neuroscience(all)
Cite this
Axonal neuropathy associated with interferon-α treatment for hepatitis C : HLA-DR immunoreactivity in Schwann cells. / Quattrini, A.; Comi, C.; Nemni, R.; Martinelli, V.; Villa, A.; Caimi, M.; Wrabetz, L.; Canal, N.
In: Acta Neuropathologica, Vol. 94, No. 5, 1997, p. 504-508.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Axonal neuropathy associated with interferon-α treatment for hepatitis C
T2 - HLA-DR immunoreactivity in Schwann cells
AU - Quattrini, A.
AU - Comi, C.
AU - Nemni, R.
AU - Martinelli, V.
AU - Villa, A.
AU - Caimi, M.
AU - Wrabetz, L.
AU - Canal, N.
PY - 1997
Y1 - 1997
N2 - A 44-year-old man developed a peripheral neuropathy during treatment with interferon-α for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.
AB - A 44-year-old man developed a peripheral neuropathy during treatment with interferon-α for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.
KW - Hepatitis C
KW - HLA-DR antigens
KW - Interferon-α
KW - Neuropathy
UR - http://www.scopus.com/inward/record.url?scp=0030813812&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030813812&partnerID=8YFLogxK
U2 - 10.1007/s004010050740
DO - 10.1007/s004010050740
M3 - Article
C2 - 9386785
AN - SCOPUS:0030813812
VL - 94
SP - 504
EP - 508
JO - Acta Neuropathologica
JF - Acta Neuropathologica
SN - 0001-6322
IS - 5
ER -