Axonal neuropathy associated with interferon-α treatment for hepatitis C: HLA-DR immunoreactivity in Schwann cells

A. Quattrini; C. Comi; R. Nemni; V. Martinelli; A. Villa; M. Caimi; L. Wrabetz; N. Canal

doi:10.1007/s004010050740

Axonal neuropathy associated with interferon-α treatment for hepatitis C: HLA-DR immunoreactivity in Schwann cells

A. Quattrini, C. Comi, R. Nemni, V. Martinelli, A. Villa, M. Caimi, L. Wrabetz, N. Canal

Research output: Contribution to journal › Article › peer-review

Abstract

A 44-year-old man developed a peripheral neuropathy during treatment with interferon-α for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.

Original language	English
Pages (from-to)	504-508
Number of pages	5
Journal	Acta Neuropathologica
Volume	94
Issue number	5
DOIs	https://doi.org/10.1007/s004010050740
Publication status	Published - 1997

Keywords

Hepatitis C
HLA-DR antigens
Interferon-α
Neuropathy

ASJC Scopus subject areas

Clinical Neurology
Pathology and Forensic Medicine
Neuroscience(all)

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10.1007/s004010050740

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abstract = "A 44-year-old man developed a peripheral neuropathy during treatment with interferon-α for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.",

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T2 - HLA-DR immunoreactivity in Schwann cells

AU - Quattrini, A.

AU - Comi, C.

AU - Nemni, R.

AU - Martinelli, V.

AU - Villa, A.

AU - Caimi, M.

AU - Wrabetz, L.

AU - Canal, N.

PY - 1997

Y1 - 1997

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AB - A 44-year-old man developed a peripheral neuropathy during treatment with interferon-α for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.

KW - Hepatitis C

KW - HLA-DR antigens

KW - Interferon-α

KW - Neuropathy

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Axonal neuropathy associated with interferon-α treatment for hepatitis C: HLA-DR immunoreactivity in Schwann cells

Abstract

Keywords

ASJC Scopus subject areas

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