Abstract
A 44-year-old man developed a peripheral neuropathy during treatment with interferon-α for chronic hepatitis C. The onset was insidious, beginning symmetrically in the hands with paresthesia. Neurophysiological investigation revealed a predominantly sensory axonal neuropathy. A sural nerve biopsy confirmed primary axonal damage. Immunofluorescence studies showed increased expression of HLA-DR molecules prevalently on Schwann cells of non-myelin-forming type.
| Original language | English |
|---|---|
| Pages (from-to) | 504-508 |
| Number of pages | 5 |
| Journal | Acta Neuropathologica |
| Volume | 94 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1997 |
Keywords
- Hepatitis C
- HLA-DR antigens
- Interferon-α
- Neuropathy
ASJC Scopus subject areas
- Clinical Neurology
- Pathology and Forensic Medicine
- Neuroscience(all)
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Cite this
Quattrini, A., Comi, C., Nemni, R., Martinelli, V., Villa, A., Caimi, M., Wrabetz, L., & Canal, N. (1997). Axonal neuropathy associated with interferon-α treatment for hepatitis C: HLA-DR immunoreactivity in Schwann cells. Acta Neuropathologica, 94(5), 504-508. https://doi.org/10.1007/s004010050740