Axonal neuropathy in a patient with monoclonal IgM kappa reactive with Schmidt-Lantermann incisures

Angelo Quattrini, Raffaello Nemni, Raffaella Fazio, Sandro Iannaccone, Isabella Lorenzetti, Franco Grassi, Nicola Canal

Research output: Contribution to journalArticlepeer-review

Abstract

We report a patient with a progressive, predominantly sensory neuropathy and a IgMκ M-protein that binds to Schmidt-Lantermann incisures. A sural nerve biopsy showed primary axonal damage and IgM deposits at Schmidt-Lantermann incisures.were seen by direct immunoperoxidase. Serum from the patient injected into rat sciatic nerve reacts with the incisures as with those in the patient's nerve. The IgMκ M-protein reacts with chondroitin sulfate C and binds to a broad nerve protein band with a mobility of between 170 and 118 kDa. Peripheral neuropathy may be related to the M-protein, which had immunocytochemical reactivity not previously described for patients with polyneuropathy and IgM monoclonal gammopathy.

Original languageEnglish
Pages (from-to)73-79
Number of pages7
JournalJournal of Neuroimmunology
Volume33
Issue number1
DOIs
Publication statusPublished - 1991

Keywords

  • Autoimmunity
  • Chondroitin sulfate C
  • Monoclonal gammopathy
  • Neuropathy
  • Schmidt-Lantermann incisure

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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