Azacitidine for the treatment of patients with acute myeloid leukemia: Report of 82 patients enrolled in an Italian compassionate program

Luca Maurillo, Adriano Venditti, Alessandra Spagnoli, Gianluca Gaidano, Dario Ferrero, Esther Oliva, Monia Lunghi, Alfonso M. D'Arco, Alessandro Levis, Domenico Pastore, Nicola Di Renzo, Alberto Santagostino, Vincenzo Pavone, Francesco Buccisano, Pellegrino Musto

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The efficacy of azacitidine for the treatment of high-risk myelodysplastic syndromes has prompted the issue of its potential role even in the treatment of acute myeloid leukemia (AML). Methods: The authors analyzed 82 patients with AML who were diagnosed according to World Health Organization criteria. The median patient age was 72 years (range, 29-87 years), and 27 patients (33%) had secondary AML. Of 62 patients with evaluable cytogenetics, 18 patients (29%) had a poor-risk karyotype, and 44 patients (71%) had an intermediate karyotype. Thirty-five patients (43%) received azacitidine as front-line treatment, and 47 patients (57%) had previously received 1 or more line of chemotherapy. Results: The overall response rate was 32% (26 of 82 patients) and included 12 (15%) complete remissions (CRs), 4 (5%) CRs with incomplete blood count recovery (CRi), and 10 (12%) partial responses (PRs). Responses were observed more frequently among untreated patients compared with pretreated patients; in fact, 17 of 35 untreated patients (48%) responded, including 11 responses (31%) classified as CR/CRi. Conversely, only 9 of 47 pretreated patients (19%) responded, including 5 responses (11%) that were classified as CR/Cri. The response rate was significantly higher for untreated patients (P =.006) and those who had white blood cell counts 9/L (P =.006). For untreated patients who achieved a response, the median overall response duration was 13 months, and the 1-year and 2-years overall survival rates were 58% and 24%, respectively. Conclusions: The current results indicated that azacitidine promises to be an effective therapy for elderly patients with untreated AML and with white blood cell counts 9/L.

Original languageEnglish
Pages (from-to)1014-1022
Number of pages9
JournalCancer
Volume118
Issue number4
DOIs
Publication statusPublished - Feb 15 2012

Keywords

  • acute myeloid leukemia
  • azacitidine
  • elderly
  • white blood cell count

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Fingerprint

Dive into the research topics of 'Azacitidine for the treatment of patients with acute myeloid leukemia: Report of 82 patients enrolled in an Italian compassionate program'. Together they form a unique fingerprint.

Cite this