Azathioprine as a single drug or in combination with steroids in the treatment of myasthenia gravis

R. Mantegazza, C. Antozzi, D. Peluchetti, A. Sghirlanzoni, F. Cornelio

Research output: Contribution to journalArticle

Abstract

Azathioprine (Aza) has been used alone or in combination with steroids for two groups of myasthenic patients. Positive responses were noted in 75% of patients on Aza alone and in 70% receiving the combined regimen. The clinical course of the two groups differed in terms of respiratory crisis and need for plasma exchange. With an appropriate Aza administration schedule side-effects were not a limiting factor to its use. Aza treatment induced a reduction in anti-AchR-antibody level that was correlated with clinical improvement and greatly decreased the need for steroids.

Original languageEnglish
Pages (from-to)449-453
Number of pages5
JournalJournal of Neurology
Volume235
Issue number8
DOIs
Publication statusPublished - Nov 1988

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Keywords

  • Azathioprine
  • Immunosuppression
  • Myasthenia gravis

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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