Azelaic acid

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Azelaic acid is a naturally occurring aliphatic C-9 dicarboxylic acid with several biological properties. The interest in the possible therapeutic applications came out in the 1980s when studies on the pathogenesis of Pityriasis versicolor, showed that in vitro dicarboxylic acids are competitive inhibitors of tyrosinase, a key enzyme for melanogenesis, leading to the use of dicarboxylic acids, and in particular azelaic acid, in the treatment of hyperpigmentary disorders. The beneficial effects of the topical application of a 20 % azelaic acid cream was proven in benign hyperpigmented disorders such as melasma and postinflammatory melanosis and effectiveness was also reported in some cases of lentigo maligna and melanoma [1, 2]. The coincidental findings of improvement in acne lesions in subjects with melasma led to new investigations on azelaic acid's properties and possible applications in acne [3].

Original languageEnglish
Title of host publicationPathogenesis and Treatment of Acne and Rosacea
PublisherSpringer-Verlag Berlin Heidelberg
Pages435-440
Number of pages6
ISBN (Print)9783540693758, 3540693742, 9783540693741
DOIs
Publication statusPublished - Nov 1 2013

ASJC Scopus subject areas

  • Medicine(all)

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