Azelaic acid is a naturally occurring aliphatic C-9 dicarboxylic acid with several biological properties. The interest in the possible therapeutic applications came out in the 1980s when studies on the pathogenesis of Pityriasis versicolor, showed that in vitro dicarboxylic acids are competitive inhibitors of tyrosinase, a key enzyme for melanogenesis, leading to the use of dicarboxylic acids, and in particular azelaic acid, in the treatment of hyperpigmentary disorders. The beneficial effects of the topical application of a 20 % azelaic acid cream was proven in benign hyperpigmented disorders such as melasma and postinflammatory melanosis and effectiveness was also reported in some cases of lentigo maligna and melanoma [1, 2]. The coincidental findings of improvement in acne lesions in subjects with melasma led to new investigations on azelaic acid's properties and possible applications in acne .
|Title of host publication||Pathogenesis and Treatment of Acne and Rosacea|
|Publisher||Springer-Verlag Berlin Heidelberg|
|Number of pages||6|
|ISBN (Print)||9783540693758, 3540693742, 9783540693741|
|Publication status||Published - Nov 1 2013|
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