AZGP1 mRNA levels in normal human lung tissue correlate with lung cancer disease status

F. S. Falvella, M. Spinola, C. Pignatiello, S. Noci, B. Conti, U. Pastorino, A. Carbone, T. A. Dragani

Research output: Contribution to journalArticlepeer-review

Abstract

Evidence in animal models has suggested an association between susceptibility to lung tumorigenesis and gene-expression profiles in normal lung. Here, we compared RNA pools from normal lung tissue of lung adenocarcinoma patients (cases) or non-lung cancer patients (controls) by hybridization of whole-human genome expression arrays. Principal component analysis identified a gene-expression signature of 85 genes that distinguishes cases from controls as well as smokers from nonsmokers. Elevated mRNA levels of one of these genes, AZGP1, were significantly associated with disease status. These results support the hypothesis that differences in the gene-expression levels of the normal tissue may be predictive of genetic predisposition to lung cancer in humans.

Original languageEnglish
Pages (from-to)1650-1656
Number of pages7
JournalOncogene
Volume27
Issue number11
DOIs
Publication statusPublished - Mar 6 2008

Keywords

  • Complex diseases
  • Gene expression
  • Genetic susceptibility
  • Inherited predisposition
  • Lung neoplasms
  • Microarray

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

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