Azoospermia and severe oligospermia in testicular cancer.

Luca Carmignani, Franco Gadda, Alessandro Paffoni, Giorgio Bozzini, Robert Stubinsky, Stefano Picozzi, Francesco Rocco

Research output: Contribution to journalArticlepeer-review


Objective: of the study is a prospective evaluation of the severe oligospermic and azoospermic patients at the moment of testicular cancer diagnosis and following curative therapies. Materials and methods: between January 2003 and December 2006 thirty-five testicular cancers were diagnosed at our institution. As soon as a testicular mass was diagnosed patients were requested to cryo conserve a semen specimen pre-orchiectomy. Overall 20 patients adhered to our recommendation. The remaining 15 patients did not follow this recommendation only due to strictly personal and psychological reasons. Results: ten patients presented severe oligospermia or azoospermia at the moment of testicular cancer diagnosis. Nine months following testicular tumour removal 9 recovered or improved their fertility passing form an azoospermia status to a mean 5.68 x 10 6 spermatozoa/ml. One patient remained azoospermic. Discussion and conclusion: in 1999 Petersen stated that the presence of so many infertile patients at the time of testis tumoural diagnosis was linked with defined genetic alterations in the other testis. These alterations were linked with severe oligospermia or azoospermia. Our study evidences how a considerable percentage of azoospermic and oligospermic patients recover fertility following definite testicular cancer therapies even if these are potentially harmful for spermatogenesis.

Original languageEnglish
Pages (from-to)21-23
Number of pages3
JournalArchivio Italiano di Urologia e Andrologia
Issue number1
Publication statusPublished - Mar 2009


  • Azoospermia
  • Fertility.
  • Testicular cancer

ASJC Scopus subject areas

  • Urology


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