B and T cell abnormalities in patients with primary IgA nephropathy

L. Cagnoli, E. Beltrandi, S. Pasquali, R. Biagi, M. Casadei-Maldini, L. Rossi, P. Zucchelli

Research output: Contribution to journalArticle

Abstract

The in vitro function of B and T cells was studied in 16 patients with primary IgA nephropahy (PIgA-N). The distribution of OKT3+ cells (total peripheral T cells) and of regulatory T cell subsets (helper OKT4+ and cytotoxic/suppressor OKT8+ cells) was evaluated and a testing for 47 HLA-A, B, C, DR, and DQ antigens was carried out in the 16. B lymphocyte IgA production, after stimulation by pokeweed mitogen in the presence of T cells from normal donors treated with mitomycin C, was significantly greater in patients than in controls. T lymphocytes from patients with PIgA-N were more efficient than T cells from controls in providing IgA specific helper activity for normal B cells. The analysis of the individual data showed that the overactivity of B cells and the T cell operational dysfunction was present in about 50% of the patients and did not correlate. No numerical imbalance between T lymphocyte subsets nor any association between lymphocyte behavior, HLA antigen distribution, and a number of clinical, laboratory, and immunohistological findings was observed. Our data, therefore, suggest that PIgA-N is an immunologically heterogeneous disease and that an IgA-specific B cell overcapacity and/or overall IgA-specific T cell helper activity may be present in some patients.

Original languageEnglish
Pages (from-to)646-651
Number of pages6
JournalKidney International
Volume28
Issue number4
Publication statusPublished - 1985

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Immunoglobulin A
B-Lymphocytes
T-Lymphocytes
T-Lymphocyte Subsets
Muromonab-CD3
Pokeweed Mitogens
HLA-A Antigens
HLA-B Antigens
Mitomycin
Regulatory T-Lymphocytes
HLA Antigens
Helper-Inducer T-Lymphocytes
Tissue Donors
Lymphocytes
Antigens

ASJC Scopus subject areas

  • Nephrology

Cite this

Cagnoli, L., Beltrandi, E., Pasquali, S., Biagi, R., Casadei-Maldini, M., Rossi, L., & Zucchelli, P. (1985). B and T cell abnormalities in patients with primary IgA nephropathy. Kidney International, 28(4), 646-651.

B and T cell abnormalities in patients with primary IgA nephropathy. / Cagnoli, L.; Beltrandi, E.; Pasquali, S.; Biagi, R.; Casadei-Maldini, M.; Rossi, L.; Zucchelli, P.

In: Kidney International, Vol. 28, No. 4, 1985, p. 646-651.

Research output: Contribution to journalArticle

Cagnoli, L, Beltrandi, E, Pasquali, S, Biagi, R, Casadei-Maldini, M, Rossi, L & Zucchelli, P 1985, 'B and T cell abnormalities in patients with primary IgA nephropathy', Kidney International, vol. 28, no. 4, pp. 646-651.
Cagnoli L, Beltrandi E, Pasquali S, Biagi R, Casadei-Maldini M, Rossi L et al. B and T cell abnormalities in patients with primary IgA nephropathy. Kidney International. 1985;28(4):646-651.
Cagnoli, L. ; Beltrandi, E. ; Pasquali, S. ; Biagi, R. ; Casadei-Maldini, M. ; Rossi, L. ; Zucchelli, P. / B and T cell abnormalities in patients with primary IgA nephropathy. In: Kidney International. 1985 ; Vol. 28, No. 4. pp. 646-651.
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AU - Pasquali, S.

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AU - Rossi, L.

AU - Zucchelli, P.

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