Abstract
The in vitro function of B and T cells was studied in 16 patients with primary IgA nephropahy (PIgA-N). The distribution of OKT3+ cells (total peripheral T cells) and of regulatory T cell subsets (helper OKT4+ and cytotoxic/suppressor OKT8+ cells) was evaluated and a testing for 47 HLA-A, B, C, DR, and DQ antigens was carried out in the 16. B lymphocyte IgA production, after stimulation by pokeweed mitogen in the presence of T cells from normal donors treated with mitomycin C, was significantly greater in patients than in controls. T lymphocytes from patients with PIgA-N were more efficient than T cells from controls in providing IgA specific helper activity for normal B cells. The analysis of the individual data showed that the overactivity of B cells and the T cell operational dysfunction was present in about 50% of the patients and did not correlate. No numerical imbalance between T lymphocyte subsets nor any association between lymphocyte behavior, HLA antigen distribution, and a number of clinical, laboratory, and immunohistological findings was observed. Our data, therefore, suggest that PIgA-N is an immunologically heterogeneous disease and that an IgA-specific B cell overcapacity and/or overall IgA-specific T cell helper activity may be present in some patients.
| Original language | English |
|---|---|
| Pages (from-to) | 646-651 |
| Number of pages | 6 |
| Journal | Kidney International |
| Volume | 28 |
| Issue number | 4 |
| Publication status | Published - 1985 |
Fingerprint
ASJC Scopus subject areas
- Nephrology
Cite this
B and T cell abnormalities in patients with primary IgA nephropathy. / Cagnoli, L.; Beltrandi, E.; Pasquali, S.; Biagi, R.; Casadei-Maldini, M.; Rossi, L.; Zucchelli, P.
In: Kidney International, Vol. 28, No. 4, 1985, p. 646-651.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - B and T cell abnormalities in patients with primary IgA nephropathy
AU - Cagnoli, L.
AU - Beltrandi, E.
AU - Pasquali, S.
AU - Biagi, R.
AU - Casadei-Maldini, M.
AU - Rossi, L.
AU - Zucchelli, P.
PY - 1985
Y1 - 1985
N2 - The in vitro function of B and T cells was studied in 16 patients with primary IgA nephropahy (PIgA-N). The distribution of OKT3+ cells (total peripheral T cells) and of regulatory T cell subsets (helper OKT4+ and cytotoxic/suppressor OKT8+ cells) was evaluated and a testing for 47 HLA-A, B, C, DR, and DQ antigens was carried out in the 16. B lymphocyte IgA production, after stimulation by pokeweed mitogen in the presence of T cells from normal donors treated with mitomycin C, was significantly greater in patients than in controls. T lymphocytes from patients with PIgA-N were more efficient than T cells from controls in providing IgA specific helper activity for normal B cells. The analysis of the individual data showed that the overactivity of B cells and the T cell operational dysfunction was present in about 50% of the patients and did not correlate. No numerical imbalance between T lymphocyte subsets nor any association between lymphocyte behavior, HLA antigen distribution, and a number of clinical, laboratory, and immunohistological findings was observed. Our data, therefore, suggest that PIgA-N is an immunologically heterogeneous disease and that an IgA-specific B cell overcapacity and/or overall IgA-specific T cell helper activity may be present in some patients.
AB - The in vitro function of B and T cells was studied in 16 patients with primary IgA nephropahy (PIgA-N). The distribution of OKT3+ cells (total peripheral T cells) and of regulatory T cell subsets (helper OKT4+ and cytotoxic/suppressor OKT8+ cells) was evaluated and a testing for 47 HLA-A, B, C, DR, and DQ antigens was carried out in the 16. B lymphocyte IgA production, after stimulation by pokeweed mitogen in the presence of T cells from normal donors treated with mitomycin C, was significantly greater in patients than in controls. T lymphocytes from patients with PIgA-N were more efficient than T cells from controls in providing IgA specific helper activity for normal B cells. The analysis of the individual data showed that the overactivity of B cells and the T cell operational dysfunction was present in about 50% of the patients and did not correlate. No numerical imbalance between T lymphocyte subsets nor any association between lymphocyte behavior, HLA antigen distribution, and a number of clinical, laboratory, and immunohistological findings was observed. Our data, therefore, suggest that PIgA-N is an immunologically heterogeneous disease and that an IgA-specific B cell overcapacity and/or overall IgA-specific T cell helper activity may be present in some patients.
UR - http://www.scopus.com/inward/record.url?scp=0022357894&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022357894&partnerID=8YFLogxK
M3 - Article
C2 - 3936964
AN - SCOPUS:0022357894
VL - 28
SP - 646
EP - 651
JO - Kidney International
JF - Kidney International
SN - 0085-2538
IS - 4
ER -