TY - JOUR
T1 - B and T cell function parameters during zidovudine treatment of human immunodeficiency virus-infected patients
AU - Zamarchi, Rita
AU - Panozzo, Marina
AU - Del Mistro, Annarosa
AU - Barelli, Andrea
AU - Borri, Alfrede
AU - Amadori, Alberto
AU - Chieco-Bianchi, Luigi
PY - 1994/11
Y1 - 1994/11
N2 - The aim of this study was to assess the effects of zidovudine on B cell dysregulation in human immunodeficiency virus (HIV)-infected patients and the phenomenon of gp120/anti-gp120 antibody complex adhesion to CD4
+ cells. Compared with pretherapy figures, zidovudine treatment was not associated with a change in spontaneous in vitro synthesis of anti-HIV antibodies but was related to restoration of lymphocyte ability to produce Epstein-Barr virus-specific antibodies in 43% of previously unresponsive patients. After 30 days of therapy, the percentage of circulating CD4
+/IgG
+ lymphocytes decreased; the number of available CD4 receptors per cell increased, and antibodies to gp120, evident in CD4
+ cell eluates from most untreated patients, were no longer detectable. These results indicate that zidovudine partly restores in vitro humoral responsiveness but does not substantially influence the overall activation of the B cell compartment. The findings also suggest that zidovudine may down-regulate some immunopathologic phenomena that amplify direct viral damage.
AB - The aim of this study was to assess the effects of zidovudine on B cell dysregulation in human immunodeficiency virus (HIV)-infected patients and the phenomenon of gp120/anti-gp120 antibody complex adhesion to CD4
+ cells. Compared with pretherapy figures, zidovudine treatment was not associated with a change in spontaneous in vitro synthesis of anti-HIV antibodies but was related to restoration of lymphocyte ability to produce Epstein-Barr virus-specific antibodies in 43% of previously unresponsive patients. After 30 days of therapy, the percentage of circulating CD4
+/IgG
+ lymphocytes decreased; the number of available CD4 receptors per cell increased, and antibodies to gp120, evident in CD4
+ cell eluates from most untreated patients, were no longer detectable. These results indicate that zidovudine partly restores in vitro humoral responsiveness but does not substantially influence the overall activation of the B cell compartment. The findings also suggest that zidovudine may down-regulate some immunopathologic phenomena that amplify direct viral damage.
UR - http://www.scopus.com/inward/record.url?scp=0028034974&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028034974&partnerID=8YFLogxK
M3 - Article
C2 - 7963707
AN - SCOPUS:0028034974
VL - 170
SP - 1148
EP - 1156
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
SN - 0022-1899
IS - 5
ER -