TY - JOUR
T1 - B cell activation and human immunodeficiency virus infection. V. Phenotypic and functional alterations in CD5+ and CD5- B cell subsets
AU - Indraccolo, Stefano
AU - Mion, Marta
AU - Zamarchi, Rita
AU - Veronesi, Arianna
AU - Veronese, Maria Luisa
AU - Panozzo, Marina
AU - Betterle, Corrado
AU - Barelli, Andrea
AU - Borri, Alfredo
AU - Amadori, Alberto
AU - Chieco-Bianchi, Luigi
PY - 1993/11
Y1 - 1993/11
N2 - B cell dysregulation is a hallmark of human immunodeficiency virus infection. Since B lymphocytes comprise two distinct subpopulations, CD5+ and CD5- cells, we addressed their individual phenotypic and functional behavior. Seropositive patients with both limited and advanced disease progression had an increased percentage of peripheral blood CD5+ B cells, compared to seronegative controls (20.1±2.1 and 22.7±5.7, respectively, vs 17.0±3.4 in controls); however, due to the lymphopenia and reduced number of circulating B cells in infected individuals, the absolute number of CD19+ CD5+ lymphocytes was actually reduced. Although HIV-specific antibodies were synthesized spontaneously in vitro only by CD5- B cells, a 10-fold lower degree of spontaneous, non-HIV-specific activation was also displayed by unstimulated CD5+ B cells. These findings indicate that B cell dysregulation during HIV infection involves both the CD5- and the CD5+ B cell compartments; moreover, in view of the putative role of CD5+ B cells in autoimmune phenomena and IL-10 production, these data reinforce the possibility that B cell dysfunction might be causally involved in AIDS pathogenesis.
AB - B cell dysregulation is a hallmark of human immunodeficiency virus infection. Since B lymphocytes comprise two distinct subpopulations, CD5+ and CD5- cells, we addressed their individual phenotypic and functional behavior. Seropositive patients with both limited and advanced disease progression had an increased percentage of peripheral blood CD5+ B cells, compared to seronegative controls (20.1±2.1 and 22.7±5.7, respectively, vs 17.0±3.4 in controls); however, due to the lymphopenia and reduced number of circulating B cells in infected individuals, the absolute number of CD19+ CD5+ lymphocytes was actually reduced. Although HIV-specific antibodies were synthesized spontaneously in vitro only by CD5- B cells, a 10-fold lower degree of spontaneous, non-HIV-specific activation was also displayed by unstimulated CD5+ B cells. These findings indicate that B cell dysregulation during HIV infection involves both the CD5- and the CD5+ B cell compartments; moreover, in view of the putative role of CD5+ B cells in autoimmune phenomena and IL-10 production, these data reinforce the possibility that B cell dysfunction might be causally involved in AIDS pathogenesis.
KW - AIDS
KW - anti-HIV antibody
KW - B lymphocytes
KW - CD5
KW - human immunodeficiency virus (HIV)
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U2 - 10.1007/BF00920013
DO - 10.1007/BF00920013
M3 - Article
C2 - 7507125
AN - SCOPUS:0027488037
VL - 13
SP - 381
EP - 388
JO - Journal of Clinical Immunology
JF - Journal of Clinical Immunology
SN - 0271-9142
IS - 6
ER -