B cell clonality in gastric lymphoid tissues of patients with Sjögren's syndrome

Gianfranco F. Ferraccioli, Dario Sorrentino, Salvatore De Vita, Lucia Casatta, Antonella Labombarda, Claudio Avellini, Riccardo Dolcetti, Dario Di Luca, Carlo Alberto Beltrami, Mauro Boiocchi, Ettore Bartoli

Research output: Contribution to journalArticlepeer-review


Objective - To determine the prevalence of mucosa associated lymphoid tissue (MALT) in the stomach and of a possible antigen driven proliferation, in patients with Sjögren's syndrome (SS). Methods - Twenty one patients with primary SS and 80 dyspeptic controls underwent upper endoscopy. Lymphoid tissue and Helicobacter pylori were assessed by histopathological analysis. Epstein-Barr virus (EBV) or human herpes virus-6 (HHV-6) genome were studied by polymerase chain reaction (PCR) DNA amplification. Two PCR VDJ procedures were used to detect immunoglobulin heavy chain (IgH) gene rearrangement. Results - Organised MALT was found in 33.3% of the patients, compared with 21.5% of the controls (NS). H pylori infection was seen in 71% of patients and 63% of controls. Genomic EBV or HHV-6 was found in a minor portion of SS gastric tissues. B cell expansion was detected in nine of the 21 patients. Infectious agents in the stomach might have contributed to B cell clonality only in 55.5% of the cases. No strict relationship was found between lymphoid follicles and clonality. Conclusion - Lymphoid accumulation in the gastric mucosa is common in Sjögren's syndrome, but full evidence for an antigen driven B cell expansion could not be demonstrated. Only a portion of those with clonal B cell expansion had evidence of an infectious agent. Other unknown infectious agents or factors related to the underlying disease (auto-antigen) and its tissue environment may have a further role as possible causes of B clonal expansion in the gastric mucosa.

Original languageEnglish
Pages (from-to)311-316
Number of pages6
JournalAnnals of the Rheumatic Diseases
Issue number5
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Immunology
  • Rheumatology


Dive into the research topics of 'B cell clonality in gastric lymphoid tissues of patients with Sjögren's syndrome'. Together they form a unique fingerprint.

Cite this