B cell clonality in multiple localizations of primary central nervous system lymphomas in AIDS patients

Emanuela Pilozzi, Caterina Talerico, Stefania Uccini, Maria Addesso, Roberta Rossi, Luca Vago, Andrea Antinori, Luigi Ruco

Research output: Contribution to journalArticlepeer-review

Abstract

The aim of our study was to investigate B cell clonality of distinct localizations of primary central nervous system lymphomas (PCNSL) in AIDS patients. We selected seven autoptic cases of AIDS PCNSL with at least two separated localizations of the disease in the central nervous system (CNS). Clonality was investigated by immunoglobulin light chain restriction and by semi-nested PCR for the immunoglobulin heavy chain (IgH). Three cases showed a concordant restriction in the two lesions. In an additional case, an identical IgH sequence was found. The remaining three cases did not provide consistent information because of extensive necrosis in the lesions. Our findings suggest that multifocality of PCNSL is due to dissemination of a single neoplastic clone rather than to a synchronous transformation of multiple B cell clones.

Original languageEnglish
Pages (from-to)963-966
Number of pages4
JournalLeukemia and Lymphoma
Volume44
Issue number6
DOIs
Publication statusPublished - Jun 1 2003

Keywords

  • Central nervous system
  • Clonality
  • Immunoglobulin heavy chain restriction
  • Primary central nervous system lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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