B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals

Florienne Loder, Bettina Mutschler, Robert J. Ray, Christopher J. Paige, Paschalis Sideras, Raul Torres, Marinus C. Lamers, Rita Carsetti

Research output: Contribution to journalArticle

618 Citations (Scopus)

Abstract

Only mature B lymphocytes can enter the lymphoid follicles of spleen and lymph nodes and thus efficiently participate in the immune response. Mature, long-lived B lymphocytes derive from short-lived precursors generated in the bone marrow. We show that selection into the mature pool is an active process and takes place in the spleen. Two populations of splenic B cell were identified as precursors for mature B cells. Transitional B cells of type 1 (T1) are recent immigrants from the bone marrow. They develop into the transitional B cells of type 2 (T2), which are cycling and found exclusively in the primary follicles of the spleen. Mature B cells can be generated fro T1 or T2 B cells. Mice with genetic deletions of elements participating in the B cell receptor signaling cascade display developmental arrest at the T1 or T2 stage. The analysis of these defects showed that the development of T2 and mature B cells from T1 precursors requires defined qualitative and quantitative signals derived from the B cell receptor and that the induction of longevity and maturation requires different signals.

Original languageEnglish
Pages (from-to)75-89
Number of pages15
JournalJournal of Experimental Medicine
Volume190
Issue number1
DOIs
Publication statusPublished - Jul 5 1999

Fingerprint

B-Lymphocytes
Spleen
B-Lymphoid Precursor Cells
Bone Marrow
Lymph Nodes
Population

Keywords

  • B cell development
  • Bruton's tyrosine kinase
  • CD45
  • Spleen
  • Transitional B cells

ASJC Scopus subject areas

  • Immunology

Cite this

B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. / Loder, Florienne; Mutschler, Bettina; Ray, Robert J.; Paige, Christopher J.; Sideras, Paschalis; Torres, Raul; Lamers, Marinus C.; Carsetti, Rita.

In: Journal of Experimental Medicine, Vol. 190, No. 1, 05.07.1999, p. 75-89.

Research output: Contribution to journalArticle

Loder, Florienne ; Mutschler, Bettina ; Ray, Robert J. ; Paige, Christopher J. ; Sideras, Paschalis ; Torres, Raul ; Lamers, Marinus C. ; Carsetti, Rita. / B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals. In: Journal of Experimental Medicine. 1999 ; Vol. 190, No. 1. pp. 75-89.
@article{7246c56c61f44284a4d531ae3591f659,
title = "B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals",
abstract = "Only mature B lymphocytes can enter the lymphoid follicles of spleen and lymph nodes and thus efficiently participate in the immune response. Mature, long-lived B lymphocytes derive from short-lived precursors generated in the bone marrow. We show that selection into the mature pool is an active process and takes place in the spleen. Two populations of splenic B cell were identified as precursors for mature B cells. Transitional B cells of type 1 (T1) are recent immigrants from the bone marrow. They develop into the transitional B cells of type 2 (T2), which are cycling and found exclusively in the primary follicles of the spleen. Mature B cells can be generated fro T1 or T2 B cells. Mice with genetic deletions of elements participating in the B cell receptor signaling cascade display developmental arrest at the T1 or T2 stage. The analysis of these defects showed that the development of T2 and mature B cells from T1 precursors requires defined qualitative and quantitative signals derived from the B cell receptor and that the induction of longevity and maturation requires different signals.",
keywords = "B cell development, Bruton's tyrosine kinase, CD45, Spleen, Transitional B cells",
author = "Florienne Loder and Bettina Mutschler and Ray, {Robert J.} and Paige, {Christopher J.} and Paschalis Sideras and Raul Torres and Lamers, {Marinus C.} and Rita Carsetti",
year = "1999",
month = "7",
day = "5",
doi = "10.1084/jem.190.1.75",
language = "English",
volume = "190",
pages = "75--89",
journal = "Journal of Experimental Medicine",
issn = "0022-1007",
publisher = "Rockefeller University Press",
number = "1",

}

TY - JOUR

T1 - B cell development in the spleen takes place in discrete steps and is determined by the quality of B cell receptor-derived signals

AU - Loder, Florienne

AU - Mutschler, Bettina

AU - Ray, Robert J.

AU - Paige, Christopher J.

AU - Sideras, Paschalis

AU - Torres, Raul

AU - Lamers, Marinus C.

AU - Carsetti, Rita

PY - 1999/7/5

Y1 - 1999/7/5

N2 - Only mature B lymphocytes can enter the lymphoid follicles of spleen and lymph nodes and thus efficiently participate in the immune response. Mature, long-lived B lymphocytes derive from short-lived precursors generated in the bone marrow. We show that selection into the mature pool is an active process and takes place in the spleen. Two populations of splenic B cell were identified as precursors for mature B cells. Transitional B cells of type 1 (T1) are recent immigrants from the bone marrow. They develop into the transitional B cells of type 2 (T2), which are cycling and found exclusively in the primary follicles of the spleen. Mature B cells can be generated fro T1 or T2 B cells. Mice with genetic deletions of elements participating in the B cell receptor signaling cascade display developmental arrest at the T1 or T2 stage. The analysis of these defects showed that the development of T2 and mature B cells from T1 precursors requires defined qualitative and quantitative signals derived from the B cell receptor and that the induction of longevity and maturation requires different signals.

AB - Only mature B lymphocytes can enter the lymphoid follicles of spleen and lymph nodes and thus efficiently participate in the immune response. Mature, long-lived B lymphocytes derive from short-lived precursors generated in the bone marrow. We show that selection into the mature pool is an active process and takes place in the spleen. Two populations of splenic B cell were identified as precursors for mature B cells. Transitional B cells of type 1 (T1) are recent immigrants from the bone marrow. They develop into the transitional B cells of type 2 (T2), which are cycling and found exclusively in the primary follicles of the spleen. Mature B cells can be generated fro T1 or T2 B cells. Mice with genetic deletions of elements participating in the B cell receptor signaling cascade display developmental arrest at the T1 or T2 stage. The analysis of these defects showed that the development of T2 and mature B cells from T1 precursors requires defined qualitative and quantitative signals derived from the B cell receptor and that the induction of longevity and maturation requires different signals.

KW - B cell development

KW - Bruton's tyrosine kinase

KW - CD45

KW - Spleen

KW - Transitional B cells

UR - http://www.scopus.com/inward/record.url?scp=0033526816&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033526816&partnerID=8YFLogxK

U2 - 10.1084/jem.190.1.75

DO - 10.1084/jem.190.1.75

M3 - Article

VL - 190

SP - 75

EP - 89

JO - Journal of Experimental Medicine

JF - Journal of Experimental Medicine

SN - 0022-1007

IS - 1

ER -