B-cell differentiation in the CNS of patients with multiple sclerosis

Anna Corcione, Francesca Aloisi, Barbara Serafini, Elisabetta Capello, Giovanni Luigi Mancardi, Vito Pistoia, Antonio Uccelli

Research output: Contribution to journalArticle

Abstract

Clonally expanded populations of Ig variable gene-mutated B cells are found in the central nervous system (CNS) of subjects with multiple sclerosis (MS), suggesting the occurrence of a germinal center-like reaction. Recent studies have demonstrated that the cerebrospinal fluid (CSF) of MS patients is enriched with centroblasts and B cells with a memory phenotype compared to peripheral blood. In the same individuals, antibody-secreting cells (ASC) are detected in the CSF and appear to correlate with CNS inflammation. These B-cell subsets are the output of a germinal center reaction, which is likely to occur in the CNS. Recent findings suggest that the inflamed brain can become a favorable niche for B-cell survival and proliferation and, under some circumstances, sustain the formation of ectopic lymphoid structures. Thus, B cells are likely to expand and mature inside the CNS, giving rise to ASC, which may play an effector role in the pathogenesis of MS.

Original languageEnglish
Pages (from-to)549-554
Number of pages6
JournalAutoimmunity Reviews
Volume4
Issue number8
DOIs
Publication statusPublished - Nov 2005

Fingerprint

Multiple Sclerosis
Cell Differentiation
B-Lymphocytes
Central Nervous System
Antibody-Producing Cells
Germinal Center
Cerebrospinal Fluid
B-Lymphocyte Subsets
Immunoglobulin Genes
Cell Survival
Cell Proliferation
Inflammation
Phenotype
Brain
Population

Keywords

  • Antibody-secreting cells
  • B cells
  • Lymphoid neogenesis
  • Multiple sclerosis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Corcione, A., Aloisi, F., Serafini, B., Capello, E., Mancardi, G. L., Pistoia, V., & Uccelli, A. (2005). B-cell differentiation in the CNS of patients with multiple sclerosis. Autoimmunity Reviews, 4(8), 549-554. https://doi.org/10.1016/j.autrev.2005.04.012

B-cell differentiation in the CNS of patients with multiple sclerosis. / Corcione, Anna; Aloisi, Francesca; Serafini, Barbara; Capello, Elisabetta; Mancardi, Giovanni Luigi; Pistoia, Vito; Uccelli, Antonio.

In: Autoimmunity Reviews, Vol. 4, No. 8, 11.2005, p. 549-554.

Research output: Contribution to journalArticle

Corcione, A, Aloisi, F, Serafini, B, Capello, E, Mancardi, GL, Pistoia, V & Uccelli, A 2005, 'B-cell differentiation in the CNS of patients with multiple sclerosis', Autoimmunity Reviews, vol. 4, no. 8, pp. 549-554. https://doi.org/10.1016/j.autrev.2005.04.012
Corcione, Anna ; Aloisi, Francesca ; Serafini, Barbara ; Capello, Elisabetta ; Mancardi, Giovanni Luigi ; Pistoia, Vito ; Uccelli, Antonio. / B-cell differentiation in the CNS of patients with multiple sclerosis. In: Autoimmunity Reviews. 2005 ; Vol. 4, No. 8. pp. 549-554.
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