B-cell lymphoma presenting as acute pancreatitis

Edda Federico, Massimo Falconi, Gianni Zuodar, Giovanni Falconieri, Fabio Puglisi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background: Pancreatic lymphoma is uncommon, representing less than 0.5% of pancreatic tumors, with diffuse large B-cell lymphoma being the predominant histotype. Acute pancreatitis associated with pancreatic lymphoma is rare. Case Report: We describe a case of synchronous pancreatic and pulmonary localizations of non-Hodgkin's lymphoma in a 42-year-old man who presented with acute pancreatitis. Acute pancreatitis resolved after standard treatment with a fasting regimen, gabexate mesilate and parenteral nutrition. However, ultrasound scan and abdominal computed tomography revealed two hypoechogenic areas within the pancreas, and chest X-ray film showed a pulmonary infiltrate in the right basal field. A percutaneous fine-needle aspiration biopsy of the pulmonary infiltrate under computed tomography guidance demonstrated a diffuse infiltration by atypical lymphoid cells positive for leukocyte common antigen, CD20 and CD30. Percutaneous fine-needle aspiration biopsy under ultrasound guidance of the pancreatic mass confirmed the diagnosis of diffuse large B-cell lymphoma. The patient was classified as stage IV-A, low-intermediate risk and received 6 cycles of chemotherapy. Conclusion: This is the first case of large B-cell lymphoma presenting with concomitant primary pancreatic and pulmonary involvement. Pancreatic lymphoma is uncommon and represents a rare cause of acute pancreatitis. The discovery of a pancreatic mass needs pathologic diagnosis to distinguish lymphoma from carcinoma or autoimmune pancreatitis.

Original languageEnglish
Pages (from-to)553-556
Number of pages4
JournalPancreatology
Volume11
Issue number6
DOIs
Publication statusPublished - Feb 2012

Fingerprint

B-Cell Lymphoma
Pancreatitis
Lymphoma
Lung
Lymphoma, Large B-Cell, Diffuse
Fine Needle Biopsy
Gabexate
Tomography
CD45 Antigens
X-Ray Film
Parenteral Nutrition
Non-Hodgkin's Lymphoma
Pancreas
Fasting
Thorax
Lymphocytes
Carcinoma
Drug Therapy
Neoplasms

Keywords

  • Acute pancreatitis
  • Pancreatic lymphoma
  • Pulmonary lymphoma

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Hepatology

Cite this

Federico, E., Falconi, M., Zuodar, G., Falconieri, G., & Puglisi, F. (2012). B-cell lymphoma presenting as acute pancreatitis. Pancreatology, 11(6), 553-556. https://doi.org/10.1159/000332038

B-cell lymphoma presenting as acute pancreatitis. / Federico, Edda; Falconi, Massimo; Zuodar, Gianni; Falconieri, Giovanni; Puglisi, Fabio.

In: Pancreatology, Vol. 11, No. 6, 02.2012, p. 553-556.

Research output: Contribution to journalArticle

Federico, E, Falconi, M, Zuodar, G, Falconieri, G & Puglisi, F 2012, 'B-cell lymphoma presenting as acute pancreatitis', Pancreatology, vol. 11, no. 6, pp. 553-556. https://doi.org/10.1159/000332038
Federico E, Falconi M, Zuodar G, Falconieri G, Puglisi F. B-cell lymphoma presenting as acute pancreatitis. Pancreatology. 2012 Feb;11(6):553-556. https://doi.org/10.1159/000332038
Federico, Edda ; Falconi, Massimo ; Zuodar, Gianni ; Falconieri, Giovanni ; Puglisi, Fabio. / B-cell lymphoma presenting as acute pancreatitis. In: Pancreatology. 2012 ; Vol. 11, No. 6. pp. 553-556.
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