Abstract
B-cell lymphomas encompass a large number of disease entities clinically ranging from indolent to aggressive. The defining pathological features usually predict clinical course, with small and large B-cell lymphomas correlating to low-grade vs high-grade features, but discordant situations may be encountered. Two sessions of the workshop of the XVIII meeting of the European Association for Haematopathology (EAHP) held in Basel in 2016 addressed this topic. One session illustrated various facets of “aggressiveness” in indolent lymphomas, either peculiar clinical manifestations, cytological variants, or unusual genetic features, as well as several examples of progression or transformation to a more aggressive disease. Another session exemplified large B-cell lymphomas with unexpected indolent behavior including cases arising in well-defined body compartments or in sanctuary sites. This paper describes the features of the cases presented in both groups, highlights the most salient points of discussion raised by the submitters and the panel, and summarizes current knowledge and recommendations relevant to diagnostic pathology practice.
| Original language | English |
|---|---|
| Pages (from-to) | 439-451 |
| Number of pages | 13 |
| Journal | Virchows Archiv |
| Volume | 471 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Oct 1 2017 |
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Keywords
- B-cell lymphomas
- Clinical behavior
- Cytology
- Discordance
- Genetics
- Pathological features
- Progression
- Transformation
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Molecular Biology
- Cell Biology
Cite this
B-cell lymphomas with discordance between pathological features and clinical behavior. / de Leval, Laurence; Copie-Bergman, Christiane; Rosenwald, Andreas; Rimsza, Lisa; Pittaluga, Stefania; Bisig, Bettina; Dirnhofer, Stefan; Facchetti, Fabio; Pileri, Stefano; Fend, Falko; Wotherspoon, Andrew.
In: Virchows Archiv, Vol. 471, No. 4, 01.10.2017, p. 439-451.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - B-cell lymphomas with discordance between pathological features and clinical behavior
AU - de Leval, Laurence
AU - Copie-Bergman, Christiane
AU - Rosenwald, Andreas
AU - Rimsza, Lisa
AU - Pittaluga, Stefania
AU - Bisig, Bettina
AU - Dirnhofer, Stefan
AU - Facchetti, Fabio
AU - Pileri, Stefano
AU - Fend, Falko
AU - Wotherspoon, Andrew
PY - 2017/10/1
Y1 - 2017/10/1
N2 - B-cell lymphomas encompass a large number of disease entities clinically ranging from indolent to aggressive. The defining pathological features usually predict clinical course, with small and large B-cell lymphomas correlating to low-grade vs high-grade features, but discordant situations may be encountered. Two sessions of the workshop of the XVIII meeting of the European Association for Haematopathology (EAHP) held in Basel in 2016 addressed this topic. One session illustrated various facets of “aggressiveness” in indolent lymphomas, either peculiar clinical manifestations, cytological variants, or unusual genetic features, as well as several examples of progression or transformation to a more aggressive disease. Another session exemplified large B-cell lymphomas with unexpected indolent behavior including cases arising in well-defined body compartments or in sanctuary sites. This paper describes the features of the cases presented in both groups, highlights the most salient points of discussion raised by the submitters and the panel, and summarizes current knowledge and recommendations relevant to diagnostic pathology practice.
AB - B-cell lymphomas encompass a large number of disease entities clinically ranging from indolent to aggressive. The defining pathological features usually predict clinical course, with small and large B-cell lymphomas correlating to low-grade vs high-grade features, but discordant situations may be encountered. Two sessions of the workshop of the XVIII meeting of the European Association for Haematopathology (EAHP) held in Basel in 2016 addressed this topic. One session illustrated various facets of “aggressiveness” in indolent lymphomas, either peculiar clinical manifestations, cytological variants, or unusual genetic features, as well as several examples of progression or transformation to a more aggressive disease. Another session exemplified large B-cell lymphomas with unexpected indolent behavior including cases arising in well-defined body compartments or in sanctuary sites. This paper describes the features of the cases presented in both groups, highlights the most salient points of discussion raised by the submitters and the panel, and summarizes current knowledge and recommendations relevant to diagnostic pathology practice.
KW - B-cell lymphomas
KW - Clinical behavior
KW - Cytology
KW - Discordance
KW - Genetics
KW - Pathological features
KW - Progression
KW - Transformation
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UR - http://www.scopus.com/inward/citedby.url?scp=85020092557&partnerID=8YFLogxK
U2 - 10.1007/s00428-017-2152-9
DO - 10.1007/s00428-017-2152-9
M3 - Article
C2 - 28573510
AN - SCOPUS:85020092557
VL - 471
SP - 439
EP - 451
JO - Virchows Archiv - A Pathological Anatomy and Histopathology
JF - Virchows Archiv - A Pathological Anatomy and Histopathology
SN - 0945-6317
IS - 4
ER -