B-cell non-Hodgkin's lymphoma and hepatitis C virus infection: A systematic review

Eva Negri, D'Anna Little, Mauro Boiocchi, Carlo La Vecchia, Silvia Franceschi

Research output: Contribution to journalArticle

Abstract

A high prevalence of hepatitis C virus (HCV) infection in patients with B-cell non-Hodgkin's lymphoma (B-NHL) has been reported in some, but not all, studies, and the association showed a strong regional variation. We conducted a systematic review of the prevalence of HCV infection in case series of B-NHL and, when an appropriate control group was available, of the odds ratio of B-NHL associated with HCV infection. A high HCV prevalence in B-NHL was found in southern and eastern Europe, Japan and the southern United States, but not in central and northern Europe, Canada, northern United States, or a few Asian countries. Possible sources of heterogeneity and bias are discussed. The odds ratio of B-NHL for HCV infection was relatively weak, ranging from 2 to 4 in most studies. Thus, even if the observed association were causal, the percentage of cases of B-NHL attributable to HCV infection would be relatively low (10%) also in countries with a high prevalence of HCV infection in the general population, and extremely low in other countries. This may explain apparent inconsistencies between studies. Potential mechanisms of action are also discussed.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalInternational Journal of Cancer
Volume111
Issue number1
DOIs
Publication statusPublished - Aug 2004

Fingerprint

B-Cell Lymphoma
Virus Diseases
Hepacivirus
Non-Hodgkin's Lymphoma
Odds Ratio
Eastern Europe
Action Potentials
Canada
Japan
Control Groups
Population

Keywords

  • Chronic lymphocytic leukemia
  • Hepatitis C virus
  • Hodgkin's lymphoma
  • Multiple myeloma
  • Non-Hodgkin's lymphoma

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

B-cell non-Hodgkin's lymphoma and hepatitis C virus infection : A systematic review. / Negri, Eva; Little, D'Anna; Boiocchi, Mauro; La Vecchia, Carlo; Franceschi, Silvia.

In: International Journal of Cancer, Vol. 111, No. 1, 08.2004, p. 1-8.

Research output: Contribution to journalArticle

Negri, E, Little, DA, Boiocchi, M, La Vecchia, C & Franceschi, S 2004, 'B-cell non-Hodgkin's lymphoma and hepatitis C virus infection: A systematic review', International Journal of Cancer, vol. 111, no. 1, pp. 1-8. https://doi.org/10.1002/ijc.20205
Negri, Eva ; Little, D'Anna ; Boiocchi, Mauro ; La Vecchia, Carlo ; Franceschi, Silvia. / B-cell non-Hodgkin's lymphoma and hepatitis C virus infection : A systematic review. In: International Journal of Cancer. 2004 ; Vol. 111, No. 1. pp. 1-8.
@article{ce130b85856d495491dc3f7e31d4dde9,
title = "B-cell non-Hodgkin's lymphoma and hepatitis C virus infection: A systematic review",
abstract = "A high prevalence of hepatitis C virus (HCV) infection in patients with B-cell non-Hodgkin's lymphoma (B-NHL) has been reported in some, but not all, studies, and the association showed a strong regional variation. We conducted a systematic review of the prevalence of HCV infection in case series of B-NHL and, when an appropriate control group was available, of the odds ratio of B-NHL associated with HCV infection. A high HCV prevalence in B-NHL was found in southern and eastern Europe, Japan and the southern United States, but not in central and northern Europe, Canada, northern United States, or a few Asian countries. Possible sources of heterogeneity and bias are discussed. The odds ratio of B-NHL for HCV infection was relatively weak, ranging from 2 to 4 in most studies. Thus, even if the observed association were causal, the percentage of cases of B-NHL attributable to HCV infection would be relatively low (10{\%}) also in countries with a high prevalence of HCV infection in the general population, and extremely low in other countries. This may explain apparent inconsistencies between studies. Potential mechanisms of action are also discussed.",
keywords = "Chronic lymphocytic leukemia, Hepatitis C virus, Hodgkin's lymphoma, Multiple myeloma, Non-Hodgkin's lymphoma",
author = "Eva Negri and D'Anna Little and Mauro Boiocchi and {La Vecchia}, Carlo and Silvia Franceschi",
year = "2004",
month = "8",
doi = "10.1002/ijc.20205",
language = "English",
volume = "111",
pages = "1--8",
journal = "International Journal of Cancer",
issn = "0020-7136",
publisher = "Wiley-Liss Inc.",
number = "1",

}

TY - JOUR

T1 - B-cell non-Hodgkin's lymphoma and hepatitis C virus infection

T2 - A systematic review

AU - Negri, Eva

AU - Little, D'Anna

AU - Boiocchi, Mauro

AU - La Vecchia, Carlo

AU - Franceschi, Silvia

PY - 2004/8

Y1 - 2004/8

N2 - A high prevalence of hepatitis C virus (HCV) infection in patients with B-cell non-Hodgkin's lymphoma (B-NHL) has been reported in some, but not all, studies, and the association showed a strong regional variation. We conducted a systematic review of the prevalence of HCV infection in case series of B-NHL and, when an appropriate control group was available, of the odds ratio of B-NHL associated with HCV infection. A high HCV prevalence in B-NHL was found in southern and eastern Europe, Japan and the southern United States, but not in central and northern Europe, Canada, northern United States, or a few Asian countries. Possible sources of heterogeneity and bias are discussed. The odds ratio of B-NHL for HCV infection was relatively weak, ranging from 2 to 4 in most studies. Thus, even if the observed association were causal, the percentage of cases of B-NHL attributable to HCV infection would be relatively low (10%) also in countries with a high prevalence of HCV infection in the general population, and extremely low in other countries. This may explain apparent inconsistencies between studies. Potential mechanisms of action are also discussed.

AB - A high prevalence of hepatitis C virus (HCV) infection in patients with B-cell non-Hodgkin's lymphoma (B-NHL) has been reported in some, but not all, studies, and the association showed a strong regional variation. We conducted a systematic review of the prevalence of HCV infection in case series of B-NHL and, when an appropriate control group was available, of the odds ratio of B-NHL associated with HCV infection. A high HCV prevalence in B-NHL was found in southern and eastern Europe, Japan and the southern United States, but not in central and northern Europe, Canada, northern United States, or a few Asian countries. Possible sources of heterogeneity and bias are discussed. The odds ratio of B-NHL for HCV infection was relatively weak, ranging from 2 to 4 in most studies. Thus, even if the observed association were causal, the percentage of cases of B-NHL attributable to HCV infection would be relatively low (10%) also in countries with a high prevalence of HCV infection in the general population, and extremely low in other countries. This may explain apparent inconsistencies between studies. Potential mechanisms of action are also discussed.

KW - Chronic lymphocytic leukemia

KW - Hepatitis C virus

KW - Hodgkin's lymphoma

KW - Multiple myeloma

KW - Non-Hodgkin's lymphoma

UR - http://www.scopus.com/inward/record.url?scp=3042817404&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3042817404&partnerID=8YFLogxK

U2 - 10.1002/ijc.20205

DO - 10.1002/ijc.20205

M3 - Article

C2 - 15185336

AN - SCOPUS:3042817404

VL - 111

SP - 1

EP - 8

JO - International Journal of Cancer

JF - International Journal of Cancer

SN - 0020-7136

IS - 1

ER -