B-cell receptor, clinical course and prognosis in chronic lymphocytic leukaemia: The growing saga of the IGHV3 subgroup gene usage

Michele Dal-Bo, Ilaria Del Giudice, Riccardo Bomben, Daniela Capello, Francesco Bertoni, Francesco Forconi, Luca Laurenti, Davide Rossi, Antonella Zucchetto, Gabriele Pozzato, Roberto Marasca, Dimitar G. Efremov, Anna Guarini, Giovanni Del Poeta, Robin Foà, Gianluca Gaidano, Valter Gattei

Research output: Contribution to journalArticle

Abstract

The immunoglobulin heavy chain variable gene (IGHV) mutational status has been recognized as an important predictor of prognosis in chronic lymphocytic leukaemia (CLL) since 1999. More recently, other features of the B-cell receptor, such as stereotypy, have been identified as capable of refining the prognostic potential of IGHV status in the clinical assessment of CLL patients. In this context, different genes belonging to the IGHV3 subgroup, the most frequently used subgroup in CLL, have been shown to denote disease subsets that either display a bad prognosis (i.e. IGHV3-21, IGHV3-23) or are associated with particularly good clinical outcomes, including a highly stable/indolent clinical course, even prone to spontaneous regression (i.e. IGHV3-72, IGHV3-30). The present review focuses on the molecular and biological features of CLL-expressing specific genes belonging to the IGHV3 subgroup that are known to mark disease subsets with completely different clinical courses, and may be possibly related to CLL pathogenesis via antigen and/or superantigen involvement.

Original languageEnglish
Pages (from-to)3-14
Number of pages12
JournalBritish Journal of Haematology
Volume153
Issue number1
DOIs
Publication statusPublished - Apr 2011

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Keywords

  • B cell receptor
  • Chronic lymphocytic leukaemia
  • IGHV3 subgroup
  • Immunoglobulin
  • Prognosis

ASJC Scopus subject areas

  • Hematology

Cite this

Dal-Bo, M., Del Giudice, I., Bomben, R., Capello, D., Bertoni, F., Forconi, F., Laurenti, L., Rossi, D., Zucchetto, A., Pozzato, G., Marasca, R., Efremov, D. G., Guarini, A., Del Poeta, G., Foà, R., Gaidano, G., & Gattei, V. (2011). B-cell receptor, clinical course and prognosis in chronic lymphocytic leukaemia: The growing saga of the IGHV3 subgroup gene usage. British Journal of Haematology, 153(1), 3-14. https://doi.org/10.1111/j.1365-2141.2010.08440.x