B-cell repertoire reconstitution after hematopoietic stem cell transplantation in children evaluated by immunoglobulin heavy chain third complementarity determining region fingerprinting

Daniela Di Martina, Sandra Dallarsa, Paolo Terranava, Lucia Scarsa, Giuseppe Morreale, Angela Valetta

Research output: Contribution to journalArticlepeer-review

Abstract

Immunodeficiency after hematopoietic stem cell transplantation leads to a high risk of opportunistic infections. We evaluated B-lymphocyte reconstitution in 36 children by heavy chain third complementarity determining region (CDR3)-fingerprinting and immunophenotypic analysis. The time necessary to return to the. normal immunoglobulin heavy chain-CDR3 polyclonal situation was basically related to the type of transplant and this process did not recapitulate fetal ontogenesis.

Original languageEnglish
Pages (from-to)506-508
Number of pages3
JournalHaematologica
Volume89
Issue number4
Publication statusPublished - Apr 2004

Keywords

  • Allogeneic
  • Autologous HSCT
  • CDR3
  • Immunological reconstitution

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'B-cell repertoire reconstitution after hematopoietic stem cell transplantation in children evaluated by immunoglobulin heavy chain third complementarity determining region fingerprinting'. Together they form a unique fingerprint.

Cite this