B-cells and mixed cryoglobulinemia

Clodoveo Ferri; Alessandro Antonelli; Maria Teresa Mascia; Marco Sebastiani; Poupak Fallahi; Daniela Ferrari; Marco Giunti; Stefano A. Pileri; Anna Linda Zignego

doi:10.1016/j.autrev.2007.02.019

B-cells and mixed cryoglobulinemia

Clodoveo Ferri, Alessandro Antonelli, Maria Teresa Mascia, Marco Sebastiani, Poupak Fallahi, Daniela Ferrari, Marco Giunti, Stefano A. Pileri, Anna Linda Zignego

Istituto Europeo di Oncologia

Research output: Contribution to journal › Article

Abstract

Mixed cryoglobulinemia (MC) is a systemic small-vessel vasculitis; B-cell expansion is the biological substrate of the disease. It can be regarded as benign lymphoproliferative condition that may evolve to frank lymphoma. HCV infection is the main causative factor of MC, as well as of other overlapping disorders, through multifactorial and multistep pathogenetic process. HCV-related B-cell proliferation represents an important model of virus-driven autoimmune/neoplastic disorder. The term HCV syndrome is referred to a wide spectrum of both hepatic and extrahepatic disorders. The present review analyzes the complex virological, clinico-pathological, and therapeutic implications of B-cell proliferation, with or without HCV infection, in MC patients.

Original language	English
Pages (from-to)	114-120
Number of pages	7
Journal	Autoimmunity Reviews
Volume	7
Issue number	2
DOIs	https://doi.org/10.1016/j.autrev.2007.02.019
Publication status	Published - Dec 2007

Keywords

Autoimmunity
B-cells
Cryoglobulinemia
Diabetes
HCV
Lymphoma
Thyroid

ASJC Scopus subject areas

Immunology
Immunology and Allergy

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Ferri, C., Antonelli, A., Mascia, M. T., Sebastiani, M., Fallahi, P., Ferrari, D., Giunti, M., Pileri, S. A., & Zignego, A. L. (2007). B-cells and mixed cryoglobulinemia. Autoimmunity Reviews, 7(2), 114-120. https://doi.org/10.1016/j.autrev.2007.02.019

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abstract = "Mixed cryoglobulinemia (MC) is a systemic small-vessel vasculitis; B-cell expansion is the biological substrate of the disease. It can be regarded as benign lymphoproliferative condition that may evolve to frank lymphoma. HCV infection is the main causative factor of MC, as well as of other overlapping disorders, through multifactorial and multistep pathogenetic process. HCV-related B-cell proliferation represents an important model of virus-driven autoimmune/neoplastic disorder. The term HCV syndrome is referred to a wide spectrum of both hepatic and extrahepatic disorders. The present review analyzes the complex virological, clinico-pathological, and therapeutic implications of B-cell proliferation, with or without HCV infection, in MC patients.",

keywords = "Autoimmunity, B-cells, Cryoglobulinemia, Diabetes, HCV, Lymphoma, Thyroid",

author = "Clodoveo Ferri and Alessandro Antonelli and Mascia, {Maria Teresa} and Marco Sebastiani and Poupak Fallahi and Daniela Ferrari and Marco Giunti and Pileri, {Stefano A.} and Zignego, {Anna Linda}",

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AU - Ferri, Clodoveo

AU - Antonelli, Alessandro

AU - Mascia, Maria Teresa

AU - Sebastiani, Marco

AU - Fallahi, Poupak

AU - Ferrari, Daniela

AU - Giunti, Marco

AU - Pileri, Stefano A.

AU - Zignego, Anna Linda

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KW - B-cells

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KW - Diabetes

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