TY - JOUR
T1 - B-cells and mixed cryoglobulinemia
AU - Ferri, Clodoveo
AU - Antonelli, Alessandro
AU - Mascia, Maria Teresa
AU - Sebastiani, Marco
AU - Fallahi, Poupak
AU - Ferrari, Daniela
AU - Giunti, Marco
AU - Pileri, Stefano A.
AU - Zignego, Anna Linda
PY - 2007/12
Y1 - 2007/12
N2 - Mixed cryoglobulinemia (MC) is a systemic small-vessel vasculitis; B-cell expansion is the biological substrate of the disease. It can be regarded as benign lymphoproliferative condition that may evolve to frank lymphoma. HCV infection is the main causative factor of MC, as well as of other overlapping disorders, through multifactorial and multistep pathogenetic process. HCV-related B-cell proliferation represents an important model of virus-driven autoimmune/neoplastic disorder. The term HCV syndrome is referred to a wide spectrum of both hepatic and extrahepatic disorders. The present review analyzes the complex virological, clinico-pathological, and therapeutic implications of B-cell proliferation, with or without HCV infection, in MC patients.
AB - Mixed cryoglobulinemia (MC) is a systemic small-vessel vasculitis; B-cell expansion is the biological substrate of the disease. It can be regarded as benign lymphoproliferative condition that may evolve to frank lymphoma. HCV infection is the main causative factor of MC, as well as of other overlapping disorders, through multifactorial and multistep pathogenetic process. HCV-related B-cell proliferation represents an important model of virus-driven autoimmune/neoplastic disorder. The term HCV syndrome is referred to a wide spectrum of both hepatic and extrahepatic disorders. The present review analyzes the complex virological, clinico-pathological, and therapeutic implications of B-cell proliferation, with or without HCV infection, in MC patients.
KW - Autoimmunity
KW - B-cells
KW - Cryoglobulinemia
KW - Diabetes
KW - HCV
KW - Lymphoma
KW - Thyroid
UR - http://www.scopus.com/inward/record.url?scp=36148982259&partnerID=8YFLogxK
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U2 - 10.1016/j.autrev.2007.02.019
DO - 10.1016/j.autrev.2007.02.019
M3 - Article
C2 - 18035320
AN - SCOPUS:36148982259
VL - 7
SP - 114
EP - 120
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
SN - 1568-9972
IS - 2
ER -