B-cells and mixed cryoglobulinemia

Clodoveo Ferri, Alessandro Antonelli, Maria Teresa Mascia, Marco Sebastiani, Poupak Fallahi, Daniela Ferrari, Marco Giunti, Stefano A. Pileri, Anna Linda Zignego

Research output: Contribution to journalArticlepeer-review


Mixed cryoglobulinemia (MC) is a systemic small-vessel vasculitis; B-cell expansion is the biological substrate of the disease. It can be regarded as benign lymphoproliferative condition that may evolve to frank lymphoma. HCV infection is the main causative factor of MC, as well as of other overlapping disorders, through multifactorial and multistep pathogenetic process. HCV-related B-cell proliferation represents an important model of virus-driven autoimmune/neoplastic disorder. The term HCV syndrome is referred to a wide spectrum of both hepatic and extrahepatic disorders. The present review analyzes the complex virological, clinico-pathological, and therapeutic implications of B-cell proliferation, with or without HCV infection, in MC patients.

Original languageEnglish
Pages (from-to)114-120
Number of pages7
JournalAutoimmunity Reviews
Issue number2
Publication statusPublished - Dec 2007


  • Autoimmunity
  • B-cells
  • Cryoglobulinemia
  • Diabetes
  • HCV
  • Lymphoma
  • Thyroid

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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