B cells and professional APCs recruit regulatory T cells via CCL4

Richard S. Bystry, Varuna Aluvihare, Katie A. Welch, Marinos Kallikourdis, Alexander G. Betz

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Abstract

Using gene expression profiling, we show here that activation of B cells and professional antigen-presenting cells (APCs) induces the expression of common chemokines. Among these, CCL4 was the most potent chemoattractant of a CD4+CD25+ T cell population, which is a characteristic phenotype of regulatory T cells. Depletion of either regulatory T cells or CCL4 resulted in a deregulated humoral response, which culminated in the production of autoantibodies. This suggested that the recruitment of regulatory T cells to B cells and APCs by CCL4 plays a central role in the normal initiation of T cell and humoral responses, and failure to do this leads to autoimmune activation.

Original languageEnglish
Pages (from-to)1126-1132
Number of pages7
JournalNature Immunology
Volume2
Issue number12
DOIs
Publication statusPublished - 2001

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ASJC Scopus subject areas

  • Immunology

Cite this

Bystry, R. S., Aluvihare, V., Welch, K. A., Kallikourdis, M., & Betz, A. G. (2001). B cells and professional APCs recruit regulatory T cells via CCL4. Nature Immunology, 2(12), 1126-1132. https://doi.org/10.1038/ni735