B cells on the podium: regulatory roles of surface and secreted immunoglobulins

Fabrizio Manca, Daniela Fenoglio, Annalisa Kunkl, Caterina Cambiaggi, Giuseppina Li Pira, Franco Celada

Research output: Contribution to journalArticle

Abstract

A long-lasting prejudice in immunology pictures T cells as active regulatory subjects and B cells as passively regulated objects. In this article, Fabrizio Manca and colleagues discuss how the notion of a passive, regulated B cell is being superseded. The emerging hypothesis is that B lymphocytes not only capture, internalize, process and present antigens to T cells, they also - through their specific paratope - govern the patterns of enzymatic degradation, and thus are instrumental in selecting the particular T cell from which they gain help. B cells therefore influence the expression of both T- and B-cell repertoires.

Original languageEnglish
Pages (from-to)300-303
Number of pages4
JournalImmunology Today
Volume9
Issue number10
DOIs
Publication statusPublished - 1988

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B-Cell Antigen Receptors
B-Lymphocytes
T-Lymphocytes
Regulatory B-Lymphocytes
Antibody Binding Sites
Allergy and Immunology
Antigens

ASJC Scopus subject areas

  • Immunology

Cite this

B cells on the podium : regulatory roles of surface and secreted immunoglobulins. / Manca, Fabrizio; Fenoglio, Daniela; Kunkl, Annalisa; Cambiaggi, Caterina; Li Pira, Giuseppina; Celada, Franco.

In: Immunology Today, Vol. 9, No. 10, 1988, p. 300-303.

Research output: Contribution to journalArticle

Manca, Fabrizio ; Fenoglio, Daniela ; Kunkl, Annalisa ; Cambiaggi, Caterina ; Li Pira, Giuseppina ; Celada, Franco. / B cells on the podium : regulatory roles of surface and secreted immunoglobulins. In: Immunology Today. 1988 ; Vol. 9, No. 10. pp. 300-303.
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