B cells on the podium: regulatory roles of surface and secreted immunoglobulins

Fabrizio Manca, Daniela Fenoglio, Annalisa Kunkl, Caterina Cambiaggi, Giuseppina Li Pira, Franco Celada

Research output: Contribution to journalArticlepeer-review


A long-lasting prejudice in immunology pictures T cells as active regulatory subjects and B cells as passively regulated objects. In this article, Fabrizio Manca and colleagues discuss how the notion of a passive, regulated B cell is being superseded. The emerging hypothesis is that B lymphocytes not only capture, internalize, process and present antigens to T cells, they also - through their specific paratope - govern the patterns of enzymatic degradation, and thus are instrumental in selecting the particular T cell from which they gain help. B cells therefore influence the expression of both T- and B-cell repertoires.

Original languageEnglish
Pages (from-to)300-303
Number of pages4
JournalImmunology Today
Issue number10
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Immunology


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