TY - JOUR
T1 - B cells on the podium
T2 - regulatory roles of surface and secreted immunoglobulins
AU - Manca, Fabrizio
AU - Fenoglio, Daniela
AU - Kunkl, Annalisa
AU - Cambiaggi, Caterina
AU - Li Pira, Giuseppina
AU - Celada, Franco
PY - 1988
Y1 - 1988
N2 - A long-lasting prejudice in immunology pictures T cells as active regulatory subjects and B cells as passively regulated objects. In this article, Fabrizio Manca and colleagues discuss how the notion of a passive, regulated B cell is being superseded. The emerging hypothesis is that B lymphocytes not only capture, internalize, process and present antigens to T cells, they also - through their specific paratope - govern the patterns of enzymatic degradation, and thus are instrumental in selecting the particular T cell from which they gain help. B cells therefore influence the expression of both T- and B-cell repertoires.
AB - A long-lasting prejudice in immunology pictures T cells as active regulatory subjects and B cells as passively regulated objects. In this article, Fabrizio Manca and colleagues discuss how the notion of a passive, regulated B cell is being superseded. The emerging hypothesis is that B lymphocytes not only capture, internalize, process and present antigens to T cells, they also - through their specific paratope - govern the patterns of enzymatic degradation, and thus are instrumental in selecting the particular T cell from which they gain help. B cells therefore influence the expression of both T- and B-cell repertoires.
UR - http://www.scopus.com/inward/record.url?scp=0023766831&partnerID=8YFLogxK
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U2 - 10.1016/0167-5699(88)91321-7
DO - 10.1016/0167-5699(88)91321-7
M3 - Article
C2 - 3076398
AN - SCOPUS:0023766831
VL - 9
SP - 300
EP - 303
JO - Immunology Today
JF - Immunology Today
SN - 0167-5699
IS - 10
ER -