Abstract
A long-lasting prejudice in immunology pictures T cells as active regulatory subjects and B cells as passively regulated objects. In this article, Fabrizio Manca and colleagues discuss how the notion of a passive, regulated B cell is being superseded. The emerging hypothesis is that B lymphocytes not only capture, internalize, process and present antigens to T cells, they also - through their specific paratope - govern the patterns of enzymatic degradation, and thus are instrumental in selecting the particular T cell from which they gain help. B cells therefore influence the expression of both T- and B-cell repertoires.
| Original language | English |
|---|---|
| Pages (from-to) | 300-303 |
| Number of pages | 4 |
| Journal | Immunology Today |
| Volume | 9 |
| Issue number | 10 |
| DOIs | |
| Publication status | Published - 1988 |
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ASJC Scopus subject areas
- Immunology
Cite this
B cells on the podium : regulatory roles of surface and secreted immunoglobulins. / Manca, Fabrizio; Fenoglio, Daniela; Kunkl, Annalisa; Cambiaggi, Caterina; Li Pira, Giuseppina; Celada, Franco.
In: Immunology Today, Vol. 9, No. 10, 1988, p. 300-303.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - B cells on the podium
T2 - regulatory roles of surface and secreted immunoglobulins
AU - Manca, Fabrizio
AU - Fenoglio, Daniela
AU - Kunkl, Annalisa
AU - Cambiaggi, Caterina
AU - Li Pira, Giuseppina
AU - Celada, Franco
PY - 1988
Y1 - 1988
N2 - A long-lasting prejudice in immunology pictures T cells as active regulatory subjects and B cells as passively regulated objects. In this article, Fabrizio Manca and colleagues discuss how the notion of a passive, regulated B cell is being superseded. The emerging hypothesis is that B lymphocytes not only capture, internalize, process and present antigens to T cells, they also - through their specific paratope - govern the patterns of enzymatic degradation, and thus are instrumental in selecting the particular T cell from which they gain help. B cells therefore influence the expression of both T- and B-cell repertoires.
AB - A long-lasting prejudice in immunology pictures T cells as active regulatory subjects and B cells as passively regulated objects. In this article, Fabrizio Manca and colleagues discuss how the notion of a passive, regulated B cell is being superseded. The emerging hypothesis is that B lymphocytes not only capture, internalize, process and present antigens to T cells, they also - through their specific paratope - govern the patterns of enzymatic degradation, and thus are instrumental in selecting the particular T cell from which they gain help. B cells therefore influence the expression of both T- and B-cell repertoires.
UR - http://www.scopus.com/inward/record.url?scp=0023766831&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023766831&partnerID=8YFLogxK
U2 - 10.1016/0167-5699(88)91321-7
DO - 10.1016/0167-5699(88)91321-7
M3 - Article
C2 - 3076398
AN - SCOPUS:0023766831
VL - 9
SP - 300
EP - 303
JO - Immunology Today
JF - Immunology Today
SN - 0167-5699
IS - 10
ER -