B-IGEV (bortezomib plus IGEV) versus IGEV before high-dose chemotherapy followed by autologous stem cell transplantation in relapsed or refractory Hodgkin lymphoma: a randomized, phase II trial of the Fondazione Italiana Linfomi (FIL)

Monica Balzarotti, Ercole Brusamolino, E. Angelucci, Angelo Michele Carella, U. Vitolo, Eleonora Russo, Angelagiovanna Congiu, Manuel Gotti, Stefania Massidda, B. Botto, Giorgia Annechini, Michele Spina, Alessandro Re, Vittorio Ruggero Zilioli, Francesco Merli, Flavia Salvi, Caterina Stelitano, Maurizio Bonfichi, Marcello Rodari, Roberta MurruMassimo Magagnoli, Antonella Anastasia, Rita Mazza, Laura Giordano, Armando Santoro

Research output: Contribution to journalArticle

Abstract

This randomized, multicenter study evaluates the addition of bortezomib (13 mg/m2) to IGEV (B-IGEV) in patients with relapsed/refractory Hodgkin Lymphoma (HL). Patients received either four courses of IGEV alone (n = 40) or B-IGEV (n = 40). The primary endpoint was the complete response (CR) proportion, evaluated by FDG-PET, after induction chemotherapy. CR proportion was 39% with B-IGEV and 53% with IGEV. PFS and OS were similar between the two groups (two-year PFS: 58% vs 56%; two-year OS: 93% vs 81%). The PET-negative status after treatment was the only variable favorably influencing both PFS (two-year PFS: 77% vs 40%; p = 0.002) and OS (two-year OS: 100% vs 76%; p 

Original languageEnglish
Pages (from-to)2375-81
Number of pages7
JournalLeukemia and Lymphoma
Volume57
Issue number10
DOIs
Publication statusPublished - Oct 1 2016

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Stem Cell Transplantation
Hodgkin Disease
Drug Therapy
Induction Chemotherapy
Multicenter Studies
Bortezomib
Therapeutics

Keywords

  • Chemotherapeutic approaches
  • clinical results
  • lymphoma and Hodgkin lymphoma

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

Cite this

B-IGEV (bortezomib plus IGEV) versus IGEV before high-dose chemotherapy followed by autologous stem cell transplantation in relapsed or refractory Hodgkin lymphoma : a randomized, phase II trial of the Fondazione Italiana Linfomi (FIL). / Balzarotti, Monica; Brusamolino, Ercole; Angelucci, E.; Carella, Angelo Michele; Vitolo, U.; Russo, Eleonora; Congiu, Angelagiovanna; Gotti, Manuel; Massidda, Stefania; Botto, B.; Annechini, Giorgia; Spina, Michele; Re, Alessandro; Zilioli, Vittorio Ruggero; Merli, Francesco; Salvi, Flavia; Stelitano, Caterina; Bonfichi, Maurizio; Rodari, Marcello; Murru, Roberta; Magagnoli, Massimo; Anastasia, Antonella; Mazza, Rita; Giordano, Laura; Santoro, Armando.

In: Leukemia and Lymphoma, Vol. 57, No. 10, 01.10.2016, p. 2375-81.

Research output: Contribution to journalArticle

Balzarotti, Monica ; Brusamolino, Ercole ; Angelucci, E. ; Carella, Angelo Michele ; Vitolo, U. ; Russo, Eleonora ; Congiu, Angelagiovanna ; Gotti, Manuel ; Massidda, Stefania ; Botto, B. ; Annechini, Giorgia ; Spina, Michele ; Re, Alessandro ; Zilioli, Vittorio Ruggero ; Merli, Francesco ; Salvi, Flavia ; Stelitano, Caterina ; Bonfichi, Maurizio ; Rodari, Marcello ; Murru, Roberta ; Magagnoli, Massimo ; Anastasia, Antonella ; Mazza, Rita ; Giordano, Laura ; Santoro, Armando. / B-IGEV (bortezomib plus IGEV) versus IGEV before high-dose chemotherapy followed by autologous stem cell transplantation in relapsed or refractory Hodgkin lymphoma : a randomized, phase II trial of the Fondazione Italiana Linfomi (FIL). In: Leukemia and Lymphoma. 2016 ; Vol. 57, No. 10. pp. 2375-81.
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AU - Balzarotti, Monica

AU - Brusamolino, Ercole

AU - Angelucci, E.

AU - Carella, Angelo Michele

AU - Vitolo, U.

AU - Russo, Eleonora

AU - Congiu, Angelagiovanna

AU - Gotti, Manuel

AU - Massidda, Stefania

AU - Botto, B.

AU - Annechini, Giorgia

AU - Spina, Michele

AU - Re, Alessandro

AU - Zilioli, Vittorio Ruggero

AU - Merli, Francesco

AU - Salvi, Flavia

AU - Stelitano, Caterina

AU - Bonfichi, Maurizio

AU - Rodari, Marcello

AU - Murru, Roberta

AU - Magagnoli, Massimo

AU - Anastasia, Antonella

AU - Mazza, Rita

AU - Giordano, Laura

AU - Santoro, Armando

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