B lymphocyte subsets and their functional activity in the early months of life

M. A. Avanzini; R. Maccario; C. Belloni; G. Carrera; A. Bertaina; M. Cagliuso; M. La Rocca; C. Valsecchi; M. Mantelli; A. M. Castellazzi; I. Quinti; A. De Silvestri; M. Marconi

B lymphocyte subsets and their functional activity in the early months of life

M. A. Avanzini, R. Maccario, C. Belloni, G. Carrera, A. Bertaina, M. Cagliuso, M. La Rocca, C. Valsecchi, M. Mantelli, A. M. Castellazzi, I. Quinti, A. De Silvestri, M. Marconi

Research output: Contribution to journal › Article › peer-review

Abstract

In the present study we evaluated B-cell subsets and their functional development in 74 newborns from birth to 6 months of life. Moreover, we evaluated "natural antibody" production in vitro. The results documented a predominance of naive B-lymphocytes at all time-points evaluated, decreasing from birth to 6 months (p=0.009). The percentages of CD27 ⁺IgD⁺ and CD27⁺I gD^neg memory B-cells were very low at birth and significantly increased only at 6 months (p=0.02 and p

Original language	English
Pages (from-to)	247-254
Number of pages	8
Journal	International Journal of Immunopathology and Pharmacology
Volume	23
Issue number	1
Publication status	Published - Jan 2010

Keywords

B lymphocytes
Ig production
Natural antibodies
Neonate

ASJC Scopus subject areas

Pharmacology
Immunology
Immunology and Allergy

Cite this

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AU - Avanzini, M. A.

AU - Maccario, R.

AU - Belloni, C.

AU - Carrera, G.

AU - Bertaina, A.

AU - Cagliuso, M.

AU - La Rocca, M.

AU - Valsecchi, C.

AU - Mantelli, M.

AU - Castellazzi, A. M.

AU - Quinti, I.

AU - De Silvestri, A.

AU - Marconi, M.

PY - 2010/1

Y1 - 2010/1

N2 - In the present study we evaluated B-cell subsets and their functional development in 74 newborns from birth to 6 months of life. Moreover, we evaluated "natural antibody" production in vitro. The results documented a predominance of naive B-lymphocytes at all time-points evaluated, decreasing from birth to 6 months (p=0.009). The percentages of CD27 +IgD+ and CD27+I gDneg memory B-cells were very low at birth and significantly increased only at 6 months (p=0.02 and p

AB - In the present study we evaluated B-cell subsets and their functional development in 74 newborns from birth to 6 months of life. Moreover, we evaluated "natural antibody" production in vitro. The results documented a predominance of naive B-lymphocytes at all time-points evaluated, decreasing from birth to 6 months (p=0.009). The percentages of CD27 +IgD+ and CD27+I gDneg memory B-cells were very low at birth and significantly increased only at 6 months (p=0.02 and p

KW - B lymphocytes

KW - Ig production

KW - Natural antibodies

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B lymphocyte subsets and their functional activity in the early months of life

Abstract

Keywords

ASJC Scopus subject areas

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