B lymphocyte subsets and their functional activity in the early months of life

M. A. Avanzini, R. Maccario, C. Belloni, G. Carrera, A. Bertaina, M. Cagliuso, M. La Rocca, C. Valsecchi, M. Mantelli, A. M. Castellazzi, I. Quinti, A. De Silvestri, M. Marconi

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Abstract

In the present study we evaluated B-cell subsets and their functional development in 74 newborns from birth to 6 months of life. Moreover, we evaluated "natural antibody" production in vitro. The results documented a predominance of naive B-lymphocytes at all time-points evaluated, decreasing from birth to 6 months (p=0.009). The percentages of CD27 +IgD+ and CD27+I gDneg memory B-cells were very low at birth and significantly increased only at 6 months (p=0.02 and p

Original languageEnglish
Pages (from-to)247-254
Number of pages8
JournalInternational Journal of Immunopathology and Pharmacology
Volume23
Issue number1
Publication statusPublished - Jan 2010

Keywords

  • B lymphocytes
  • Ig production
  • Natural antibodies
  • Neonate

ASJC Scopus subject areas

  • Pharmacology
  • Immunology
  • Immunology and Allergy

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    Avanzini, M. A., Maccario, R., Belloni, C., Carrera, G., Bertaina, A., Cagliuso, M., La Rocca, M., Valsecchi, C., Mantelli, M., Castellazzi, A. M., Quinti, I., De Silvestri, A., & Marconi, M. (2010). B lymphocyte subsets and their functional activity in the early months of life. International Journal of Immunopathology and Pharmacology, 23(1), 247-254.