B vitamins and homocysteine in mild cognitive impairment and dementia

P. Quadri, C. Fragiacomo, R. Pezzati, E. Zanda, M. Tettamanti, Ugo Lucca

Research output: Contribution to journalArticlepeer-review


The aim of our research was to investigate the relationships of mild cognitive impairment and dementia (Alzheimer's disease and vascular dementia) with blood vitamin B-12, folate and homocysteine concentrations. Of the 314 consecutive subjects seen, 228 were included in the analyses: 55 non-demented elderly controls, 81 CDR 0.5 subjects, and 92 demented patients. Adjusted odds ratio for mild cognitive impairment (OR = 3.1) and dementia (OR = 3.8) were significantly higher in subjects in the lowest folate tertile. Dementia was also significantly associated with hyperhomocysteinemia (adjusted OR = 4.3). CDR 0.5 subjects in the highest homocysteine tertile had significantly lower mean MMSE scores than individuals in the lowest (p <0.05). These findings indicate that relative folate deficiency may already be present in a preclinical phase of dementia, while the risk associated with hyperhomocysteinemia for dementia development needs to be confirmed in further longitudinal studies.

Original languageEnglish
Pages (from-to)82-88
Number of pages7
JournalResearch and Practice in Alzheimer's Disease
Publication statusPublished - 2005


  • Dementia
  • Folate
  • Homocysteine
  • Mild cognitive impairment
  • Vitamin B-12

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Neuropsychology and Physiological Psychology


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