Abstract
In patients with metabolic syndrome, body iron overload exacerbates insulin resistance, impairment of glucose metabolism, endothelium dysfunction and coronary artery responses. Conversely, iron depletion is effective to ameliorate glucose metabolism and dysfunctional endothelium. Most of its effectiveness seems to occur through the amelioration of systemic and hepatic insulin resistance.In a study published by BMC Medicine, Michalsen et al. demonstrated a dramatic improvement of blood pressure, serum glucose and lipids after removing 550 to 800 ml of blood in subjects with metabolic syndrome. This effect was apparently independent of changes in insulin resistance, in contrast to previous cross-sectional and cohort studies investigating the association between iron overload, insulin resistance and cardiovascular disease.Despite drawbacks in the study design, its findings may lead the way to investigations aimed at exploring iron-dependent regulatory mechanisms of vascular tone in healthy individuals and patients with metabolic disease, thus providing a rationale for novel preventive and therapeutic strategies to counteract hypertension.Please see related article: http://www.biomedcentral.com/1741-7015/10/54.
| Original language | English |
|---|---|
| Article number | 53 |
| Journal | BMC Medicine |
| Volume | 10 |
| DOIs | |
| Publication status | Published - May 30 2012 |
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Keywords
- Blood pressure
- Insulin sensitivity
- Iron
- Metabolic syndrome
- Phlebotomy
ASJC Scopus subject areas
- Medicine(all)
Cite this
Back to past leeches : Repeated phlebotomies and cardiovascular risk. / Manco, Melania; Fernandez-Real, Josè M.
In: BMC Medicine, Vol. 10, 53, 30.05.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Back to past leeches
T2 - Repeated phlebotomies and cardiovascular risk
AU - Manco, Melania
AU - Fernandez-Real, Josè M.
PY - 2012/5/30
Y1 - 2012/5/30
N2 - In patients with metabolic syndrome, body iron overload exacerbates insulin resistance, impairment of glucose metabolism, endothelium dysfunction and coronary artery responses. Conversely, iron depletion is effective to ameliorate glucose metabolism and dysfunctional endothelium. Most of its effectiveness seems to occur through the amelioration of systemic and hepatic insulin resistance.In a study published by BMC Medicine, Michalsen et al. demonstrated a dramatic improvement of blood pressure, serum glucose and lipids after removing 550 to 800 ml of blood in subjects with metabolic syndrome. This effect was apparently independent of changes in insulin resistance, in contrast to previous cross-sectional and cohort studies investigating the association between iron overload, insulin resistance and cardiovascular disease.Despite drawbacks in the study design, its findings may lead the way to investigations aimed at exploring iron-dependent regulatory mechanisms of vascular tone in healthy individuals and patients with metabolic disease, thus providing a rationale for novel preventive and therapeutic strategies to counteract hypertension.Please see related article: http://www.biomedcentral.com/1741-7015/10/54.
AB - In patients with metabolic syndrome, body iron overload exacerbates insulin resistance, impairment of glucose metabolism, endothelium dysfunction and coronary artery responses. Conversely, iron depletion is effective to ameliorate glucose metabolism and dysfunctional endothelium. Most of its effectiveness seems to occur through the amelioration of systemic and hepatic insulin resistance.In a study published by BMC Medicine, Michalsen et al. demonstrated a dramatic improvement of blood pressure, serum glucose and lipids after removing 550 to 800 ml of blood in subjects with metabolic syndrome. This effect was apparently independent of changes in insulin resistance, in contrast to previous cross-sectional and cohort studies investigating the association between iron overload, insulin resistance and cardiovascular disease.Despite drawbacks in the study design, its findings may lead the way to investigations aimed at exploring iron-dependent regulatory mechanisms of vascular tone in healthy individuals and patients with metabolic disease, thus providing a rationale for novel preventive and therapeutic strategies to counteract hypertension.Please see related article: http://www.biomedcentral.com/1741-7015/10/54.
KW - Blood pressure
KW - Insulin sensitivity
KW - Iron
KW - Metabolic syndrome
KW - Phlebotomy
UR - http://www.scopus.com/inward/record.url?scp=84861552988&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84861552988&partnerID=8YFLogxK
U2 - 10.1186/1741-7015-10-53
DO - 10.1186/1741-7015-10-53
M3 - Article
C2 - 22647488
AN - SCOPUS:84861552988
VL - 10
JO - BMC Medicine
JF - BMC Medicine
SN - 1741-7015
M1 - 53
ER -