Abstract
Autologous platelet gel, which is usually prepared by adding thrombin and calcium to a platelet concentrate, is used to accelerate bone repair as a possible alternative to recombinant growth factors (GF), through the osteogenic GF released from a-granules. The advantages of platelet gel lie in its mimicking the GF effects of the physiological bone healing and regenerative processes, in addition to a relatively simple and low cost technique. Moreover, if autologous platelet gel is used, immunological reactions are avoided. In in vitro systems, platelet gel stimulated osteogenic differentiation of bone marrow stromal cells, while it inhibited complete osteoclast differentiation and activation. Moreover, platelet gel favoured endothelial cell proliferation and expression of pro-osteogenic functions. In experimental animals and in clinical application, the efficacy of platelet gel was increased by the combination with bone allografts, acting as scaffolds, and with bone marrow stromal cells.
| Original language | English |
|---|---|
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Musculoskeletal Surgery |
| Volume | 94 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2010 |
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Keywords
- Bone regeneration
- Growth factor
- Platelet gel
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Surgery
- Medicine(all)
Cite this
Background and rationale of platelet gel in orthopaedic surgery. / Cenni, Elisabetta; Savarino, Lucia; Perut, Francesca; Fotia, Caterina; Avnet, Sofia; Sabbioni, Giacomo.
In: Musculoskeletal Surgery, Vol. 94, No. 1, 2010, p. 1-8.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Background and rationale of platelet gel in orthopaedic surgery
AU - Cenni, Elisabetta
AU - Savarino, Lucia
AU - Perut, Francesca
AU - Fotia, Caterina
AU - Avnet, Sofia
AU - Sabbioni, Giacomo
PY - 2010
Y1 - 2010
N2 - Autologous platelet gel, which is usually prepared by adding thrombin and calcium to a platelet concentrate, is used to accelerate bone repair as a possible alternative to recombinant growth factors (GF), through the osteogenic GF released from a-granules. The advantages of platelet gel lie in its mimicking the GF effects of the physiological bone healing and regenerative processes, in addition to a relatively simple and low cost technique. Moreover, if autologous platelet gel is used, immunological reactions are avoided. In in vitro systems, platelet gel stimulated osteogenic differentiation of bone marrow stromal cells, while it inhibited complete osteoclast differentiation and activation. Moreover, platelet gel favoured endothelial cell proliferation and expression of pro-osteogenic functions. In experimental animals and in clinical application, the efficacy of platelet gel was increased by the combination with bone allografts, acting as scaffolds, and with bone marrow stromal cells.
AB - Autologous platelet gel, which is usually prepared by adding thrombin and calcium to a platelet concentrate, is used to accelerate bone repair as a possible alternative to recombinant growth factors (GF), through the osteogenic GF released from a-granules. The advantages of platelet gel lie in its mimicking the GF effects of the physiological bone healing and regenerative processes, in addition to a relatively simple and low cost technique. Moreover, if autologous platelet gel is used, immunological reactions are avoided. In in vitro systems, platelet gel stimulated osteogenic differentiation of bone marrow stromal cells, while it inhibited complete osteoclast differentiation and activation. Moreover, platelet gel favoured endothelial cell proliferation and expression of pro-osteogenic functions. In experimental animals and in clinical application, the efficacy of platelet gel was increased by the combination with bone allografts, acting as scaffolds, and with bone marrow stromal cells.
KW - Bone regeneration
KW - Growth factor
KW - Platelet gel
UR - http://www.scopus.com/inward/record.url?scp=77956218951&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77956218951&partnerID=8YFLogxK
U2 - 10.1007/s12306-009-0048-9
DO - 10.1007/s12306-009-0048-9
M3 - Article
C2 - 19937168
AN - SCOPUS:77956218951
VL - 94
SP - 1
EP - 8
JO - Musculoskeletal Surgery
JF - Musculoskeletal Surgery
SN - 2035-5106
IS - 1
ER -