Baclofen in the treatment of persistent hiccup: A case series

A. Mirijello; G. Addolorato; C. D'Angelo; A. Ferrulli; G. Vassallo; M. Antonelli; L. Leggio; R. Landolfi

doi:10.1111/ijcp.12184

Baclofen in the treatment of persistent hiccup: A case series

A. Mirijello, G. Addolorato, C. D'Angelo, A. Ferrulli, G. Vassallo, M. Antonelli, L. Leggio, R. Landolfi

Research output: Contribution to journal › Article › peer-review

Abstract

Background Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments. Aim To test baclofen administration for the treatment of persistent hiccup. Method We report a series of seven patients affected by persistent hiccup successfully treated with baclofen. Results Hiccup stopped in all patients after a single administration of the drug. Conclusions Baclofen is a GABA_B receptor agonist. It is conceivable that the reduction of dopamine release by GABA_B receptor stimulation is able to interrupt hiccup's reflex arc.

Original language	English
Pages (from-to)	918-921
Number of pages	4
Journal	International Journal of Clinical Practice
Volume	67
Issue number	9
DOIs	https://doi.org/10.1111/ijcp.12184
Publication status	Published - Sep 2013

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Medicine(all)

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abstract = "Background Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments. Aim To test baclofen administration for the treatment of persistent hiccup. Method We report a series of seven patients affected by persistent hiccup successfully treated with baclofen. Results Hiccup stopped in all patients after a single administration of the drug. Conclusions Baclofen is a GABAB receptor agonist. It is conceivable that the reduction of dopamine release by GABAB receptor stimulation is able to interrupt hiccup's reflex arc.",

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AU - Mirijello, A.

AU - Addolorato, G.

AU - D'Angelo, C.

AU - Ferrulli, A.

AU - Vassallo, G.

AU - Antonelli, M.

AU - Leggio, L.

AU - Landolfi, R.

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AB - Background Persistent hiccup is a worrying symptom both for patients, because of reduced quality of life, and for physicians, because of frustration for unsuccessful treatments. Aim To test baclofen administration for the treatment of persistent hiccup. Method We report a series of seven patients affected by persistent hiccup successfully treated with baclofen. Results Hiccup stopped in all patients after a single administration of the drug. Conclusions Baclofen is a GABAB receptor agonist. It is conceivable that the reduction of dopamine release by GABAB receptor stimulation is able to interrupt hiccup's reflex arc.

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Baclofen in the treatment of persistent hiccup: A case series

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