TY - JOUR
T1 - Bacterial adhesion to respiratory mucosa and its modulation by antibiotics at sub-inhibitory concentrations
AU - Piatti, Gioia
PY - 1994
Y1 - 1994
N2 - Respiratory infections develop after contact and successive adhesion of micro-organisms to airway mucosa. In fact, the bacterial adhesins are able to interact with a 'lock and key' mechanism with the analogous structures on epithelial surfaces when permissive conditions occur. It was observed that antibiotics at sub-inhibitory concentrations (sub-MICs) can modify bacterial ability of adhesion to host cells, in various ways. Bacterial adhesion is generally inhibited by antibiotics that, at these concentrations, do not kill bacteria but can change the surface architecture of the micro-organisms.
AB - Respiratory infections develop after contact and successive adhesion of micro-organisms to airway mucosa. In fact, the bacterial adhesins are able to interact with a 'lock and key' mechanism with the analogous structures on epithelial surfaces when permissive conditions occur. It was observed that antibiotics at sub-inhibitory concentrations (sub-MICs) can modify bacterial ability of adhesion to host cells, in various ways. Bacterial adhesion is generally inhibited by antibiotics that, at these concentrations, do not kill bacteria but can change the surface architecture of the micro-organisms.
KW - antibiotics
KW - respiratory infections
KW - subinhibitory concentrations
UR - http://www.scopus.com/inward/record.url?scp=0028577226&partnerID=8YFLogxK
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U2 - 10.1016/1043-6618(94)80009-X
DO - 10.1016/1043-6618(94)80009-X
M3 - Article
C2 - 7716103
AN - SCOPUS:0028577226
VL - 30
SP - 289
EP - 299
JO - Pharmacological Research
JF - Pharmacological Research
SN - 1043-6618
IS - 4
ER -