Abstract
Introduction. During the 2010/11 influenza season an epidemiological prospective cohort active study was organized, to evaluate etiologic role due to the main bacteria and viruses causing Community Acquired Pneumonia (CAP) and Influenza like-illness (ILI) in elderly and to explore the role of the bacterial nose-pharingeal carriage in subjects with respiratory tract infections. Methods. An integrated active surveillance of a cohort of adults aged ≥ 60 y based on a double prospective and retrospective mechanisms of capture of ILI and CAP cases was organized. Samples were collected from all ILI and CAP prospectively identified. The samples were be tested by multiplex PCR for detection of the main respiratory bacteria and viruses. Results and discussion. The study population amounted to 2,551 adults. During the 2010/11 influenza season, the ILI cumulative incidence was 4.2%, that was twice higher than that calculated by regional sentinel-based Influenza surveillance system during the 2010/11 season in the elderly (2.2%). Among 45 patients with ILI of which had been collected the swab, 17 (37.8%) were positive for influenza viruses and 2 (4.4%) for RSV, 6 (13.3%) patients carried Streptococcus pn and 6 (13.3%) Haemophilus in. In the same period, 7 CAP cases were observed; 3 cases were prospectively identified and samples were collected, while 4 cases were retrospectively detected. The CAP cumulative incidence was 0,3%. The influenza vaccine effectiveness in prevention of laboratory-confirmed influenza emerged by our study was 61%, in condition of good antigenic matching between vaccine and circulating strains observed during the 2010/11. These data contribute to better defining the epidemiological picture of upper and lower respiratory tract infections, fundamental information in light of the recent introduction of new vaccines for prevention of pneumonia in the elderly, including 13-valent conjugate pneumococcal vaccine.
| Original language | English |
|---|---|
| Pages (from-to) | 94-97 |
| Number of pages | 4 |
| Journal | Journal of Preventive Medicine and Hygiene |
| Volume | 53 |
| Issue number | 2 |
| Publication status | Published - Jun 2012 |
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Keywords
- Elderly
- Influenza
- Pneumococcus
ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Infectious Diseases
Cite this
Bacterial carriage and respiratory tract infections in subjects ≥ 60 years during an influenza season : Implications for the epidemiology of Community Acquired Pneumonia and influenza vaccine effectiveness. / Ansaldi, F.; De Florentiis, D.; Parodi, V.; RapPazzo, E.; Coppelli, M.; Martini, M.; Alicino, C.; Durando, P.; Icardi, G.
In: Journal of Preventive Medicine and Hygiene, Vol. 53, No. 2, 06.2012, p. 94-97.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Bacterial carriage and respiratory tract infections in subjects ≥ 60 years during an influenza season
T2 - Implications for the epidemiology of Community Acquired Pneumonia and influenza vaccine effectiveness
AU - Ansaldi, F.
AU - De Florentiis, D.
AU - Parodi, V.
AU - RapPazzo, E.
AU - Coppelli, M.
AU - Martini, M.
AU - Alicino, C.
AU - Durando, P.
AU - Icardi, G.
PY - 2012/6
Y1 - 2012/6
N2 - Introduction. During the 2010/11 influenza season an epidemiological prospective cohort active study was organized, to evaluate etiologic role due to the main bacteria and viruses causing Community Acquired Pneumonia (CAP) and Influenza like-illness (ILI) in elderly and to explore the role of the bacterial nose-pharingeal carriage in subjects with respiratory tract infections. Methods. An integrated active surveillance of a cohort of adults aged ≥ 60 y based on a double prospective and retrospective mechanisms of capture of ILI and CAP cases was organized. Samples were collected from all ILI and CAP prospectively identified. The samples were be tested by multiplex PCR for detection of the main respiratory bacteria and viruses. Results and discussion. The study population amounted to 2,551 adults. During the 2010/11 influenza season, the ILI cumulative incidence was 4.2%, that was twice higher than that calculated by regional sentinel-based Influenza surveillance system during the 2010/11 season in the elderly (2.2%). Among 45 patients with ILI of which had been collected the swab, 17 (37.8%) were positive for influenza viruses and 2 (4.4%) for RSV, 6 (13.3%) patients carried Streptococcus pn and 6 (13.3%) Haemophilus in. In the same period, 7 CAP cases were observed; 3 cases were prospectively identified and samples were collected, while 4 cases were retrospectively detected. The CAP cumulative incidence was 0,3%. The influenza vaccine effectiveness in prevention of laboratory-confirmed influenza emerged by our study was 61%, in condition of good antigenic matching between vaccine and circulating strains observed during the 2010/11. These data contribute to better defining the epidemiological picture of upper and lower respiratory tract infections, fundamental information in light of the recent introduction of new vaccines for prevention of pneumonia in the elderly, including 13-valent conjugate pneumococcal vaccine.
AB - Introduction. During the 2010/11 influenza season an epidemiological prospective cohort active study was organized, to evaluate etiologic role due to the main bacteria and viruses causing Community Acquired Pneumonia (CAP) and Influenza like-illness (ILI) in elderly and to explore the role of the bacterial nose-pharingeal carriage in subjects with respiratory tract infections. Methods. An integrated active surveillance of a cohort of adults aged ≥ 60 y based on a double prospective and retrospective mechanisms of capture of ILI and CAP cases was organized. Samples were collected from all ILI and CAP prospectively identified. The samples were be tested by multiplex PCR for detection of the main respiratory bacteria and viruses. Results and discussion. The study population amounted to 2,551 adults. During the 2010/11 influenza season, the ILI cumulative incidence was 4.2%, that was twice higher than that calculated by regional sentinel-based Influenza surveillance system during the 2010/11 season in the elderly (2.2%). Among 45 patients with ILI of which had been collected the swab, 17 (37.8%) were positive for influenza viruses and 2 (4.4%) for RSV, 6 (13.3%) patients carried Streptococcus pn and 6 (13.3%) Haemophilus in. In the same period, 7 CAP cases were observed; 3 cases were prospectively identified and samples were collected, while 4 cases were retrospectively detected. The CAP cumulative incidence was 0,3%. The influenza vaccine effectiveness in prevention of laboratory-confirmed influenza emerged by our study was 61%, in condition of good antigenic matching between vaccine and circulating strains observed during the 2010/11. These data contribute to better defining the epidemiological picture of upper and lower respiratory tract infections, fundamental information in light of the recent introduction of new vaccines for prevention of pneumonia in the elderly, including 13-valent conjugate pneumococcal vaccine.
KW - Elderly
KW - Influenza
KW - Pneumococcus
UR - http://www.scopus.com/inward/record.url?scp=84864649898&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84864649898&partnerID=8YFLogxK
M3 - Article
C2 - 23240167
AN - SCOPUS:84864649898
VL - 53
SP - 94
EP - 97
JO - Journal of Preventive Medicine and Hygiene
JF - Journal of Preventive Medicine and Hygiene
SN - 1121-2233
IS - 2
ER -