TY - JOUR
T1 - Bacterial infection in patients with advanced cirrhosis
T2 - A multicentre prospective study
AU - Borzio, M.
AU - Salerno, F.
AU - Piantoni, L.
AU - Cazzaniga, M.
AU - Angeli, P.
AU - Bissoli, F.
AU - Boccia, S.
AU - Colloredo-Mels, G.
AU - Corigliano, P.
AU - Fornaciari, G.
AU - Marenco, G.
AU - Pistarà, R.
AU - Salvagnini, M.
AU - Sangiovanni, A.
PY - 2001
Y1 - 2001
N2 - Aims. To evaluate the prevalence, incidence and clinical relevance of bacterial infection in predominantly non-alcoholic cirrhotic patients hospitalised for decompensation. Patients/Methods. A total of 405 consecutive admissions in 361 patients (249 males and 112 females; 66 Child-Pugh class B and 295 class C) were analysed. Blood, urine, ascitic and pleural fluid cultures were performed within the first 24 hours, during hospitalisation whenever infection was suspected, and again before discharge. Results. Over a one year period, 150 (34%) bacterial infections (89 community- and 61 hospital-acquired) involving urinary tract (41%), ascites (23%), blood (21%) and respiratory tract (17%) were diagnosed. The prevalence of bacterial peritonitis was 12%. Infections were asymptomatic in 69 cases (46%) and 130 (87%) involved a single site. Enteric flora accounted for 62% of infections, Escherichia Coli being the most frequent pathogen (25%). Community-acquired infections were associated with more advanced liver disease (Child-Pugh mean score 10.2±2.1 versus 9,5±1.9, p
AB - Aims. To evaluate the prevalence, incidence and clinical relevance of bacterial infection in predominantly non-alcoholic cirrhotic patients hospitalised for decompensation. Patients/Methods. A total of 405 consecutive admissions in 361 patients (249 males and 112 females; 66 Child-Pugh class B and 295 class C) were analysed. Blood, urine, ascitic and pleural fluid cultures were performed within the first 24 hours, during hospitalisation whenever infection was suspected, and again before discharge. Results. Over a one year period, 150 (34%) bacterial infections (89 community- and 61 hospital-acquired) involving urinary tract (41%), ascites (23%), blood (21%) and respiratory tract (17%) were diagnosed. The prevalence of bacterial peritonitis was 12%. Infections were asymptomatic in 69 cases (46%) and 130 (87%) involved a single site. Enteric flora accounted for 62% of infections, Escherichia Coli being the most frequent pathogen (25%). Community-acquired infections were associated with more advanced liver disease (Child-Pugh mean score 10.2±2.1 versus 9,5±1.9, p
KW - Bacterial infections
KW - Cirrhosis
UR - http://www.scopus.com/inward/record.url?scp=0035111136&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035111136&partnerID=8YFLogxK
M3 - Article
C2 - 11303974
AN - SCOPUS:0035111136
VL - 33
SP - 41
EP - 48
JO - Digestive and Liver Disease
JF - Digestive and Liver Disease
SN - 1590-8658
IS - 1
ER -